UniProt Accession

 MET14_HUMAN; Q9HCE5; A6NIG1; Q969V2 

Genbank Protein ID

 AB046847; AK055555; AC110079; CH471229; BC006565; BC007449 

Genbank Nucleotide ID

 BAB13453.1; BAB70954.1; EAW73651.1; AAH06565.1; AAH07449.1 

Protein Name

 Methyltransferase-like protein 14 

Protein Synonyms/Alias

  

Gene Name

 METTL14 

Gene Synonyms/Alias

 KIAA1627 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
38	IGAVLNSKDEQREIA	ubiquitination	[1, 2]
148	DRFEEYPKLRELIRL	ubiquitination	[1, 2, 3]
156	LRELIRLKDELIAKS	ubiquitination	[2]
185	DIRELTPKFDVILLE	ubiquitination	[1]
278	KTKTLDPKAVFQRTK	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Probable methyltransferase (By similarity). 

Sequence Annotation

  

Keyword

 Coiled coil; Complete proteome; Methyltransferase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 456 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0016422; F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; ISS:UniProtKB. 

Interpro

 IPR007757; MT-A70-like. 

Pfam

 PF05063; MT-A70 

SMART

  

PROSITE

 PS51143; MT_A70 

PRINTS