CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034088
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Ndufs2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
62SKETAHWKPPPWNDVacetylation[1]
278GIQWDLRKTQPYDVYubiquitination[2]
324IIEQCLNKMPPGEIKacetylation[3]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 437 AA 
Protein Sequence
MAALRALRCL RGVGAPVLRP GSGIRLPSQP SRGARQWQPD IEWAEQFSGA VMYPSKETAH 60
WKPPPWNDVD ILKEKAVTNM TLNFGPQHPA AHGVLRLVLE LSGEMVRKCD PHIGLLHRGT 120
EKLIEYKTYL QALPYFDRLD YVSMMCNEQA YSIAVEKLLN IQPPPRAQWI RVLFGEITRI 180
LNHIMAVTTH ALDIGAMTPF FWMFEEREKM FEFYERVSGA RMHAAYIRPG GVHQMLTNNR 240
IWRNRTVDIG VVTAEDALNY GFSGVMLRGS GIQWDLRKTQ PYDVYDQVEF DVPIGSRGDC 300
YDRYLCRVEE MRQSLRIIEQ CLNKMPPGEI KVDDAKVSPP KRAEMKTSME SLIHHFKLYT 360
EGYQVPPGAT YTAIEAPKGE FGVYLVSDGS SRPYRCKIKA PGFAHLAGLD KMSKGHMLAD 420
VVAIIGTQDI VFGEIDR 437 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
 GO:0048038; F:quinone binding; IEA:InterPro. 
Interpro
 IPR001135; NADH_Q_OxRdtase_suD.
 IPR014029; NADH_UbQ_OxRdtase_49kDa_CS.
 IPR022885; NDH1_su_D/H. 
Pfam
 PF00346; Complex1_49kDa 
SMART
  
PROSITE
 PS00535; COMPLEX1_49K 
PRINTS