CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021102
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 C-Jun-amino-terminal kinase-interacting protein 2 
Protein Synonyms/Alias
 JIP-2; JNK-interacting protein 2; Islet-brain-2; IB-2; JNK MAP kinase scaffold protein 2; Mitogen-activated protein kinase 8-interacting protein 2 
Gene Name
 Mapk8ip2 
Gene Synonyms/Alias
 Ib2; Jip2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
581PDLTFSKKFLNVFVNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells (By similarity). 
Sequence Annotation
 DOMAIN 610 671 SH3.
 DOMAIN 683 819 PID.
 REGION 111 278 JNK-binding domain (JBD).
 REGION 242 504 Necessary for interaction with FGF13 (By  
Keyword
 Complete proteome; Cytoplasm; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 830 AA 
Protein Sequence
MADRAEMFSL STFHSLSPPG CRPPQDISLE EFDDEDLSEI TDDCGLGLSY DSDHCEKDSL 60
SLGRSEQPHP ICSFQDDFQE FEMIDDNEEE DDEEEEEEEE EEEDGDRQGK AGGGPGSQAL 120
AGDSLIPSPS LEESHKLRPT TLHLTTLGAQ DSLNNNNGGF TSAPPSSWQE TVLRSPAQEP 180
LKELPAPLLP AEEERHEVQS LARPGCDCEG NQPPEPPASS GGASPSSDPG IEADLRSHSS 240
GGHEGRRSSQ ELSSPGSDSE DAGGARLGRM ISSISETELE LSSDGGSSSG RSSHLTNSIE 300
EASSPASEPE PEPEPLHEPP RRPAFLPVGQ DDTNSEYESG SESEPDLSED ADSPWLLSNL 360
VSRMISEGSS PIRCPGQCLS PAPRLPEEAA SQANSVPQDC QDPEAGPHVE LVDMDTLCGP 420
PPPAPAAPRL GPAQPGPCLF LSNPTRDTIT PLWATPGRTA RPGRSCSAAC SEEEEEDEEE 480
DEEDEEDAED SVVPPGSRTT GSTAPLDASL VYDAVKYTLV VDEHTQLELV SLRRCAGLGN 540
DSEEDSSCEA SEEEAGATLL GSDQVPEDAS PDSPDLTFSK KFLNVFVNST SRSSSTESFG 600
LFSCVVNGEE REQTHRAVFR FIPRHPDELE LDVDDPVLVE AEEDDFWFRG FNMRTGERGV 660
FPAFYAHAVP GPAKDLLGSK RSPCWVDRFD VQFLGSVEVP CHQGNGILCA AMQKIATARK 720
LTVHLRPPAS CDLEISLRGV KLSLSGGGPE FQRCSHFFQM KNISFCGCHP RNSCYFGFIT 780
KHPLLSRFAC HVFVSQESMR PVARSVGRAF LEYYQEHLAF ACPTEDIYLE 830 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0014069; C:postsynaptic density; IDA:BHF-UCL.
 GO:0030295; F:protein kinase activator activity; IEA:Compara.
 GO:0019901; F:protein kinase binding; ISS:UniProtKB.
 GO:0001662; P:behavioral fear response; IMP:BHF-UCL.
 GO:0048813; P:dendrite morphogenesis; IMP:BHF-UCL.
 GO:0007254; P:JNK cascade; IDA:MGI.
 GO:0007617; P:mating behavior; IMP:BHF-UCL.
 GO:0046958; P:nonassociative learning; IMP:BHF-UCL.
 GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IMP:BHF-UCL.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IMP:BHF-UCL.
 GO:0046328; P:regulation of JNK cascade; ISS:UniProtKB.
 GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; IMP:BHF-UCL.
 GO:0051966; P:regulation of synaptic transmission, glutamatergic; IMP:BHF-UCL.
 GO:0035176; P:social behavior; IMP:BHF-UCL. 
Interpro
 IPR011993; PH_like_dom.
 IPR006020; PTyr_interaction_dom.
 IPR001452; SH3_domain. 
Pfam
 PF00640; PID
 PF00018; SH3_1 
SMART
 SM00462; PTB
 SM00326; SH3 
PROSITE
 PS01179; PID
 PS50002; SH3 
PRINTS