| Tag | Content |
|---|
| CPLM ID | CPLM-018745 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphatidylinositol 3-kinase regulatory subunit gamma |
Protein Synonyms/Alias | PI3-kinase regulatory subunit gamma; PI3K regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK |
Gene Name | PIK3R3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 170 | YQQDQLVKEDNIDAV | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. |
Sequence Annotation | DOMAIN 65 160 SH2 1.
DOMAIN 358 452 SH2 2.
MOD_RES 199 199 Phosphotyrosine (By similarity).
MOD_RES 341 341 Phosphotyrosine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH2 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 461 AA |
Protein Sequence | MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTSAVP NGMKDSSVSL 60
QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY TLTLRKGGNN KLIKIYHRDG 120
KYGFSDPLTF NSVVELINHY HHESLAQYNP KLDVKLMYPV SRYQQDQLVK EDNIDAVGKK 180
LQEYHSQYQE KSKEYDRLYE EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKEY 240
IERFRREGNE KEIERIMMNY DKLKSRLGEI HDSKMRLEQD LKNQALDNRE IDKKMNSIKP 300
DLIQLRKIRD QHLVWLNHKG VRQKRLNVWL GIKNEDADEN YFINEEDENL PHYDEKTWFV 360
EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE VKHCVIYSTA RGYGFAEPYN 420
LYSSLKELVL HYQQTSLVQH NDSLNVRLAY PVHAQMPSLC R 461 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:Compara. GO:0016303; F:1-phosphatidylinositol-3-kinase activity; TAS:ProtInc. GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:Compara. GO:0008286; P:insulin receptor signaling pathway; TAS:ProtInc. GO:0043551; P:regulation of phosphatidylinositol 3-kinase activity; IEA:GOC. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |