UniProt Accession

 CD81_HUMAN; P60033; P18582; Q5U0J6 

Genbank Protein ID

 M33680; BT019507; BT019508; EF064749; AC129929; AC124057; BC002978; BC093047 

Genbank Nucleotide ID

 AAA36663.1; AAV38314.1; AAV38315.1; ABK41932.1; AAH02978.1; AAH93047.1 

Protein Name

 CD81 antigen 

Protein Synonyms/Alias

 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD81 

Gene Name

 CD81 

Gene Synonyms/Alias

 TAPA1; TSPAN28 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
121	VNKDQIAKDVKQFYD	ubiquitination	[1]
124	DQIAKDVKQFYDQAL	ubiquitination	[1, 2, 3]
144	DDDANNAKAVVKTFH	ubiquitination	[1, 2, 3]
148	NNAKAVVKTFHETLD	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV. 

Sequence Annotation

 DISULFID 156 190
 DISULFID 157 175  

Keyword

 3D-structure; Complete proteome; Disulfide bond; Host-virus interaction; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 236 AA 

Protein Sequence

Gene Ontology

 GO:0001772; C:immunological synapse; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.
 GO:0000187; P:activation of MAPK activity; IDA:UniProtKB.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0006661; P:phosphatidylinositol biosynthetic process; IDA:UniProtKB.
 GO:0043128; P:positive regulation of 1-phosphatidylinositol 4-kinase activity; IDA:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
 GO:0008104; P:protein localization; IDA:UniProtKB.
 GO:0050776; P:regulation of immune response; TAS:Reactome.
 GO:0046718; P:viral entry into host cell; TAS:UniProtKB.
 GO:0046813; P:virion attachment, binding of host cell surface receptor; TAS:UniProtKB. 

Interpro

 IPR000301; Tetraspanin.
 IPR018499; Tetraspanin/Peripherin.
 IPR018503; Tetraspanin_CS.
 IPR008952; Tetraspanin_EC2. 

Pfam

 PF00335; Tetraspannin 

SMART

  

PROSITE

 PS00421; TM4_1 

PRINTS

 PR00259; TMFOUR.