UniProt Accession

 STX1B_RAT; P61265; P32853 

Genbank Protein ID

 M95735 

Genbank Nucleotide ID

 AAA42197.1 

Protein Name

 Syntaxin-1B 

Protein Synonyms/Alias

 P35B; Syntaxin-1B2 

Gene Name

 Stx1b 

Gene Synonyms/Alias

 Stx1b2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
54	SEDVEQVKKQHSAIL	acetylation	[1]
55	EDVEQVKKQHSAILA	ubiquitination	[2]
69	AAPNPDEKTKQELED	ubiquitination	[2]
71	PNPDEKTKQELEDLT	acetylation	[1]
82	EDLTADIKKTANKVR	acetylation	[1]
91	TANKVRSKLKAIEQS	acetylation	[1]
93	NKVRSKLKAIEQSIE	acetylation	[1]
93	NKVRSKLKAIEQSIE	ubiquitination	[2]
125	QHSTLSRKFVEVMTE	ubiquitination	[2]
139	EYNATQSKYRDRCKD	acetylation	[1]
139	EYNATQSKYRDRCKD	ubiquitination	[2]
181	AIFTDDIKMDSQMTK	ubiquitination	[2]
188	KMDSQMTKQALNEIE	ubiquitination	[2]
203	TRHNEIIKLETSIRE	ubiquitination	[2]
255	SDTKKAVKYQSKARR	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). 

Sequence Annotation

 DOMAIN 191 253 t-SNARE coiled-coil homology.
 MOD_RES 14 14 Phosphoserine.
 MOD_RES 58 58 Phosphoserine (By similarity).
 MOD_RES 160 160 Phosphothreonine (By similarity).  

Keyword

 Coiled coil; Complete proteome; Direct protein sequencing; Membrane; Neurotransmitter transport; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IMP:RGD.
 GO:0017157; P:regulation of exocytosis; IMP:RGD.
 GO:0007268; P:synaptic transmission; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IMP:RGD. 

Interpro

 IPR015709; Syntaxin-1.
 IPR006012; Syntaxin/epimorphin_CS.
 IPR006011; Syntaxin_N.
 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom. 

Pfam

 PF05739; SNARE
 PF00804; Syntaxin 

SMART

 SM00503; SynN
 SM00397; t_SNARE 

PROSITE

 PS00914; SYNTAXIN
 PS50192; T_SNARE 

PRINTS