CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024456
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine protease 40 
Protein Synonyms/Alias
 Testicular serine protease 2 
Gene Name
 Prss40 
Gene Synonyms/Alias
 Tesp2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
143SRTMSVQKVIVHKDYacetylation[1]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
 May play an important role in the sperm/egg interaction; released during the acrosome reaction. 
Sequence Annotation
 DOMAIN 69 313 Peptidase S1.
 ACT_SITE 109 109 Charge relay system (By similarity).
 ACT_SITE 159 159 Charge relay system (By similarity).
 ACT_SITE 264 264 Charge relay system (By similarity).
 CARBOHYD 44 44 N-linked (GlcNAc...) (Potential).
 DISULFID 94 110 By similarity.
 DISULFID 193 270 By similarity.
 DISULFID 226 249 By similarity.
 DISULFID 260 288 By similarity.  
Keyword
 Complete proteome; Cytoplasmic vesicle; Disulfide bond; Glycoprotein; Hydrolase; Protease; Reference proteome; Secreted; Serine protease; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 365 AA 
Protein Sequence
MCGIRAKKSG LGGYGAGLLA ALLGVSFLSQ HAQTAEHVTN AANNTTIQIM KSTLSLSEVC 60
GKTKFQGKIY GGQIAGAERW PWQASLRLYG RHICGAVLID KNWVLSAAHC FQRSQEPSDY 120
HVMLGYTDLN SPTRYSRTMS VQKVIVHKDY NRFHTQGSDI VLLQLRSSVE YSSHILPACV 180
PEENIKIPKE KACWASGWGY LREDVRIPLP NELYEAELII MSNDQCKGFF PPPVPGSGRS 240
YYIYDDMVCA ADYDMSKSIC AGDSGGPLVC LLEGSWYVVG LTSWSSTCEE PIVSPSVFAR 300
VSYFDKWIKD NKKSSSNSKP GESPHHPGSP ENENPEGDNK NQGAVIKPTV CTALLLSQIL 360
LQQLI 365 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001254; Peptidase_S1.
 IPR018114; Peptidase_S1_AS.
 IPR001314; Peptidase_S1A.
 IPR009003; Trypsin-like_Pept_dom. 
Pfam
 PF00089; Trypsin 
SMART
 SM00020; Tryp_SPc 
PROSITE
 PS50240; TRYPSIN_DOM
 PS00134; TRYPSIN_HIS
 PS00135; TRYPSIN_SER 
PRINTS
 PR00722; CHYMOTRYPSIN.