CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036795
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphatidylinositol 3-kinase regulatory subunit alpha 
Protein Synonyms/Alias
  
Gene Name
 PIK3R1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
56SLAQYNPKLDVKLLYubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 137 AA 
Protein Sequence
MHGDYTLTLR KGGNNKLIKI FHRDGKYGFS DPLTFSSVVE LINHYRNESL AQYNPKLDVK 60
LLYPVSKYQQ DQVVKEDNIE AVGKKLHEYN TQFQEKSREY DRLYEEYTRT SQEIQMKRTA 120
IEAFNETIKI FEEQCQT 137 
Gene Ontology
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:InterPro.
 GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; IEA:InterPro.
 GO:0030183; P:B cell differentiation; IEA:Compara.
 GO:0034644; P:cellular response to UV; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Compara.
 GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Compara.
 GO:0051531; P:NFAT protein import into nucleus; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006468; P:protein phosphorylation; IEA:Compara.
 GO:0043551; P:regulation of phosphatidylinositol 3-kinase activity; IEA:GOC. 
Interpro
 IPR001720; PI3kinase_P85.
 IPR000980; SH2. 
Pfam
 PF00017; SH2 
SMART
 SM00252; SH2 
PROSITE
 PS50001; SH2 
PRINTS
 PR00678; PI3KINASEP85.