CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020927
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NADH-cytochrome b5 reductase 1 
Protein Synonyms/Alias
 b5R.1; NAD(P)H:quinone oxidoreductase type 3 polypeptide A2 
Gene Name
 Cyb5r1 
Gene Synonyms/Alias
 Nqo3a2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
178PELRVAKKLGMIAGGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). 
Sequence Annotation
 DOMAIN 44 156 FAD-binding FR-type.
 NP_BIND 136 166 FAD (By similarity).
 NP_BIND 175 210 FAD (By similarity).  
Keyword
 Alternative splicing; Complete proteome; FAD; Flavoprotein; Lipid biosynthesis; Lipid metabolism; Membrane; NAD; Oxidoreductase; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 305 AA 
Protein Sequence
MGIQPSPVLL ASLGVGLLTL LGLALGTYLV RRSRRPQVTL QDPDEKYLLR LLDKTTVSHN 60
TRRFRFALPT AHHILGLPVG KHVYLSARID GSLVIRPYTP VTSDEDQGYV DLVIKVYLKG 120
VHPKFPEGGK MSQYLDSLKI GDMVEFRGPS GLLSYAGKGN FNIQPNKKSP PELRVAKKLG 180
MIAGGTGITP MLQLIRAILK VPEDPTQCFL LFANQTERDI ILREDLEELQ AQYPNRFKLW 240
FTLDSPPEDW TYSKGFVTAD MIQEHLPAPA EDVLLLLCGP PPMVQLACHP NLDKLGYSQK 300
MRFTY 305 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004128; F:cytochrome-b5 reductase activity, acting on NAD(P)H; IEA:EC.
 GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR017927; Fd_Rdtase_FAD-bd.
 IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
 IPR001834; NADH-Cyt_B5_reductase.
 IPR008333; OxRdtase_FAD-bd_dom.
 IPR001433; OxRdtase_FAD/NAD-bd.
 IPR017938; Riboflavin_synthase-like_b-brl. 
Pfam
 PF00970; FAD_binding_6
 PF00175; NAD_binding_1 
SMART
  
PROSITE
 PS51384; FAD_FR 
PRINTS
 PR00406; CYTB5RDTASE.
 PR00371; FPNCR.