CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038219
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Disintegrin and metalloproteinase domain-containing protein 10 
Protein Synonyms/Alias
  
Gene Name
 Adam10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
447NISQVLEKKRNNCFVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 513 AA 
Protein Sequence
MVLPTVLILL LSWAAGLGGQ YGNPLNKYIR HYEGLSYNVD SLHQKHQRAK RAVSHEDQFL 60
LLDFHAHGRQ FNLRMKRDTS LFSDEFKVET SNKVLDYDTS HIYTGHIYGE EGSFSHGSVI 120
DGRFEGFIKT RGGTFYIEPA ERYIKDRILP FHSVIYHEDD INYPHKYGPQ GGCADHSVFE 180
RMRKYQMTGV EEGARAHPEK HAASSGPELL RKKRTTLAER NTCQLYIQTD HLFFKYYGTR 240
EAVIAQISSH VKAIDTIYQT TDFSGIRNIS FMVKRIRINT TSDEKDPTNP FRFPNIGVEK 300
FLELNSEQNH DDYCLAYVFT DRDFDDGVLG LAWVGAPSGS SGGICEKSKL YSDGKKKSLN 360
TGIITVQNYG SHVPPKVSHI TFAHEVGHNF GSPHDSGTEC TPGESKNLGQ KENGNYIMYA 420
RATSGDKLNN NKFSLCSIRN ISQVLEKKRN NCFVESGQPI CGNGMVEQGE ECDCGYSDQC 480
KDDCCFDANQ PEGKKCKLKP GKQCSTVCIQ VKV 513 
Gene Ontology
 GO:0014069; C:postsynaptic density; IDA:MGI.
 GO:0004175; F:endopeptidase activity; IDA:MGI.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006509; P:membrane protein ectodomain proteolysis; IEA:InterPro.
 GO:0007219; P:Notch signaling pathway; IEA:InterPro. 
Interpro
 IPR027053; ADAM_10.
 IPR001762; Blood-coag_inhib_Disintegrin.
 IPR024079; MetalloPept_cat_dom.
 IPR001590; Peptidase_M12B.
 IPR002870; Peptidase_M12B_N. 
Pfam
 PF00200; Disintegrin
 PF01562; Pep_M12B_propep 
SMART
 SM00050; DISIN 
PROSITE
 PS50215; ADAM_MEPRO
 PS50214; DISINTEGRIN_2 
PRINTS