CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037572
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transcriptional activator Myb 
Protein Synonyms/Alias
  
Gene Name
 MYB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
53EEDEKLKKLVEQNGTubiquitination[1, 2]
109RVIELVQKYGPKRWSubiquitination[1, 2, 3]
120KRWSVIAKHLKGRIGubiquitination[1]
144HLNPEVKKTSWTEEEubiquitination[1]
160RIIYQAHKRLGNRWAubiquitination[1]
171NRWAEIAKLLPGRTDubiquitination[1, 2]
182GRTDNAIKNHWNSTMubiquitination[1]
192WNSTMRRKVEQEGYLubiquitination[1]
204GYLQESSKASQPAVAubiquitination[1, 2]
291YNDEDPEKEKRIKELubiquitination[2, 4]
293DEDPEKEKRIKELELubiquitination[2]
296PEKEKRIKELELLLMubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 385 AA 
Protein Sequence
MARRPRHSIY SSDEDDEDFE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK LKKLVEQNGT 60
DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED QRVIELVQKY GPKRWSVIAK 120
HLKGRIGKQC RERWHNHLNP EVKKTSWTEE EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA 180
IKNHWNSTMR RKVEQEGYLQ ESSKASQPAV ATSFQKNSHL MGFAQAPPTA QLPATGQPTV 240
NNDYSYYHIS EAQNVSSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL 300
LLMSTENELK GQQTQNHTCS YPGWHSTTIA DHTRPHGDSA PVSCLGEHHS TPSLPADPGS 360
LPEESASPAR CRVSGGPCST SEGQP 385 
Gene Ontology
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR009057; Homeodomain-like.
 IPR017930; Myb_dom.
 IPR001005; SANT/Myb.
 IPR012642; Tscrpt_reg_Wos2-domain. 
Pfam
 PF07988; LMSTEN
 PF00249; Myb_DNA-binding 
SMART
 SM00717; SANT 
PROSITE
 PS51294; HTH_MYB 
PRINTS