UniProt Accession

 H0YK83_HUMAN; H0YK83 

Genbank Protein ID

 AC087732; AC115102 

Genbank Nucleotide ID

  

Protein Name

 Signal peptidase complex catalytic subunit SEC11A 

Protein Synonyms/Alias

  

Gene Name

 SEC11A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
127	VDDRGLYKQGQHWLE	ubiquitination	[1]
135	QGQHWLEKKDVVGRA	ubiquitination	[1]
136	GQHWLEKKDVVGRAR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Hydrolase; Membrane; Protease; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 185 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0006465; P:signal peptide processing; IEA:InterPro. 

Interpro

 IPR019758; Pept_S26A_signal_pept_1_CS.
 IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
 IPR019759; Peptidase_S24_S26.
 IPR015927; Peptidase_S24_S26A/B/C.
 IPR011056; Peptidase_S24_S26A/B/C_b-rbn.
 IPR001733; Peptidase_S26B. 

Pfam

 PF00717; Peptidase_S24 

SMART

  

PROSITE

 PS00501; SPASE_I_1
 PS00761; SPASE_I_3 

PRINTS

 PR00728; SIGNALPTASE.