CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002114
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Keratin, type II cytoskeletal 1 
Protein Synonyms/Alias
 67 kDa cytokeratin; Cytokeratin-1; CK-1; Hair alpha protein; Keratin-1; K1; Type-II keratin Kb1 
Gene Name
 KRT1 
Gene Synonyms/Alias
 KRTA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
276KYEDEINKRTNAENEmethylation[1]
Reference
 [1] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 
Functional Description
 May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK. 
Sequence Annotation
 REGION 2 179 Head.
 REGION 180 489 Rod.
 REGION 180 215 Coil 1A.
 REGION 216 234 Linker 1.
 REGION 235 326 Coil 1B.
 REGION 327 350 Linker 12.
 REGION 351 489 Coil 2.
 REGION 490 644 Tail.
 MOD_RES 21 21 Phosphoserine.
 MOD_RES 66 66 Phosphoserine.
 MOD_RES 82 82 Omega-N-methylarginine.
 MOD_RES 276 276 N6,N6-dimethyllysine.
 MOD_RES 344 344 Phosphoserine.  
Keyword
 Cell membrane; Citrullination; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Ichthyosis; Intermediate filament; Keratin; Membrane; Methylation; Palmoplantar keratoderma; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 644 AA 
Protein Sequence
MSRQFSSRSG YRSGGGFSSG SAGIINYQRR TTSSSTRRSG GGGGRFSSCG GGGGSFGAGG 60
GFGSRSLVNL GGSKSISISV ARGGGRGSGF GGGYGGGGFG GGGFGGGGFG GGGIGGGGFG 120
GFGSGGGGFG GGGFGGGGYG GGYGPVCPPG GIQEVTINQS LLQPLNVEID PEIQKVKSRE 180
REQIKSLNNQ FASFIDKVRF LEQQNQVLQT KWELLQQVDT STRTHNLEPY FESFINNLRR 240
RVDQLKSDQS RLDSELKNMQ DMVEDYRNKY EDEINKRTNA ENEFVTIKKD VDGAYMTKVD 300
LQAKLDNLQQ EIDFLTALYQ AELSQMQTQI SETNVILSMD NNRSLDLDSI IAEVKAQYED 360
IAQKSKAEAE SLYQSKYEEL QITAGRHGDS VRNSKIEISE LNRVIQRLRS EIDNVKKQIS 420
NLQQSISDAE QRGENALKDA KNKLNDLEDA LQQAKEDLAR LLRDYQELMN TKLALDLEIA 480
TYRTLLEGEE SRMSGECAPN VSVSVSTSHT TISGGGSRGG GGGGYGSGGS SYGSGGGSYG 540
SGGGGGGGRG SYGSGGSSYG SGGGSYGSGG GGGGHGSYGS GSSSGGYRGG SGGGGGGSSG 600
GRGSGGGSSG GSIGGRGSSS GGVKSSGGSS SVKFVSTTYS GVTR 644 
Gene Ontology
 GO:0005856; C:cytoskeleton; TAS:ProtInc.
 GO:0045095; C:keratin filament; IEA:Compara.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030246; F:carbohydrate binding; IPI:UniProtKB.
 GO:0004872; F:receptor activity; NAS:UniProtKB.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0001867; P:complement activation, lectin pathway; IPI:UniProtKB.
 GO:0042730; P:fibrinolysis; NAS:UniProtKB.
 GO:0045765; P:regulation of angiogenesis; NAS:UniProtKB.
 GO:0006979; P:response to oxidative stress; NAS:UniProtKB. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR003054; Keratin_II.
 IPR009053; Prefoldin. 
Pfam
 PF00038; Filament 
SMART
  
PROSITE
 PS00226; IF 
PRINTS
 PR01276; TYPE2KERATIN.