CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027033
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HMG coenzyme A synthase, isoform A 
Protein Synonyms/Alias
 HMG coenzyme A synthase, isoform B; HMG coenzyme A synthase, isoform C; HMG coenzyme A synthase, isoform D; HMG coenzyme A synthase, isoform E; HMG coenzyme asynthase; LD26976p 
Gene Name
 Hmgs 
Gene Synonyms/Alias
 CG4311; Dmel_CG4311 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
264PFCKLVQKSVGRLSFacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
  
Sequence Annotation
  
Keyword
 Acyltransferase; Complete proteome; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 465 AA 
Protein Sequence
MASHWPENVG IRAIEILFPS QYVDQTELET FDGASAGKYT IGLGQAKMGF CSDREDVNSL 60
CLTVVSRLLE RQHVKHSEIG RLEVGTETIV DKSKSVKSVL MQLFAESGNT DIEGIDTTNA 120
CYGGTAALFN AVNWVESSSW DGRLALAVCA DIAVYAKGAA RPTGGAGAVA MLVGPNAPLI 180
LDRGLRATHM EHAYDFYKPD LSSEYPTVDG KLSIQCYLSA LDTCYRLYRK KFDQQQKDTS 240
KQPASLSTFD AILFHTPFCK LVQKSVGRLS FNDFLLSSEE ERTKQFPDLE RFNTATLEST 300
YFDRDVEKAF MTQSANIFAS KTKKSLLLAN QVGNMYTPSV YSGLVSLLIS GPAQELVGKR 360
IGLFSYGSGL AASMYSISVT QDAAAFEKFV SQLDYVQPLL NSREKVAPEQ FSALMEVREK 420
NNHAAPYTPT GSISALFPGT YYLKDVDALH RRTYERTPTI SNGVH 465 
Gene Ontology
 GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
 GO:0001700; P:embryonic development via the syncytial blastoderm; IMP:FlyBase.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
 GO:0046331; P:lateral inhibition; IMP:FlyBase.
 GO:0022008; P:neurogenesis; IMP:FlyBase. 
Interpro
 IPR000590; HMG_CoA_synt_AS.
 IPR013746; HMG_CoA_synt_C.
 IPR013528; HMG_CoA_synth_N.
 IPR010122; HMG_CoA_synthase_euk.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr. 
Pfam
 PF08540; HMG_CoA_synt_C
 PF01154; HMG_CoA_synt_N 
SMART
  
PROSITE
 PS01226; HMG_COA_SYNTHASE 
PRINTS