UniProt Accession

 GRM1A_HUMAN; Q96CP6; A6NKY7; Q8NC77; Q9P1Z5 

Genbank Protein ID

 AK074914; AC020907; BC014077; AB040966 

Genbank Nucleotide ID

 BAC11289.1; AAH14077.2; BAA96057.1 

Protein Name

 GRAM domain-containing protein 1A 

Protein Synonyms/Alias

  

Gene Name

 GRAMD1A 

Gene Synonyms/Alias

 KIAA1533 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	GSDSSSEKGGVPGTP	ubiquitination	[1]
87	SMLSPTYKQRNEDFR	ubiquitination	[2, 3]
99	DFRKLFSKLPEAERL	ubiquitination	[2, 3, 4]
416	SPWSGDSKCHQRRVL	ubiquitination	[4]
436	ISNPLGPKSASVVET	ubiquitination	[4]
501	SSEIRYRKQPWSLVK	ubiquitination	[4]
513	LVKSLIEKNSWSGIE	ubiquitination	[4]
535	RELAKAEKLSLEEGG	ubiquitination	[4]
543	LSLEEGGKDARGLLS	ubiquitination	[4]
655	SLALAKGKFPQTATE	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 DOMAIN 91 158 GRAM.
 MOD_RES 263 263 Phosphoserine.
 MOD_RES 267 267 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 724 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 

Interpro

 IPR004182; GRAM. 

Pfam

 PF02893; GRAM 

SMART

 SM00568; GRAM 

PROSITE

  

PRINTS