Tag | Content |
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CPLM ID | CPLM-006734 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphatidylinositol 4-kinase STT4 |
Protein Synonyms/Alias | PI4-kinase; PtdIns-4-kinase |
Gene Name | STT4 |
Gene Synonyms/Alias | YLR305C; L2142.4 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
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475 | QLTITSGKNIEKDYF | ubiquitination | [1] | 479 | TSGKNIEKDYFPLRN | ubiquitination | [1] | 1175 | MEYSPYDKAGINRDA | ubiquitination | [1] |
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Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,- trisphosphate. STT4 functions in PKC1 protein kinase pathway. |
Sequence Annotation | DOMAIN 1345 1530 PIK helical. DOMAIN 1643 1882 PI3K/PI4K. REGION 1531 1648 Pleckstrin homology (PH) domain MOD_RES 459 459 Phosphoserine. |
Keyword | ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1900 AA |
Protein Sequence | MRFTRGLKAS SSLRAKAIGR LTKLSTGAPN DQNSNGTTLD LITHTLPIFY STNTSKIYTI 60 PLTLSEWEVL TSLCVAIPTT LDLVETMLKE IIAPYFLETP RQRISDVLSS KFKLEQMRNP 120 IELLTFQLTK FMIQACEQYP VLYENIGGII STYFERVLKI FTIKQSGLLS LVGFINAFIQ 180 FPNSTELTKF TWKKLAKLVL RGSFLNEVDK ILNSSATFTN DSIVQYYDAG NELSSAYLLE 240 LISRLQVSLI SHLLNTSHVG ANLSEFLLNQ QYQFYKFDQE VADENDDTKC IDDFFFNVRS 300 NKQFFTDMCK ISLQFCSESH ILDLSTDNRA RFSFDTRAHY LQTLCLIPFI EDTESELFES 360 FTNVVSESID KFFLSDVVTP SLIKAIVASA SLLNFFTEKL SLTLIRMFPL LVASPHITTE 420 TVNDVAKIFT TGLYPLNEDA IVSTIYSMNN LLAVSEDGSP VPVLRERQLT ITSGKNIEKD 480 YFPLRNSSAS LDGTGALLGN TTVGQLSSHD VNSGATMTYH ASLISNCVAA TTTIASYYNT 540 QSITALTISI LTQKVNSMSK ELDGVILNSL ARLAPNTSLT EFSLLLKFFK SRTVIATKID 600 DSALLKNIIK AKCVISKELL ARHFSSDLYF MYLHDLLDSI IASGEVERLE HHRPQTEISR 660 VADQIATYLE PLAALLPVPG DTPLDINKDE VTTNKFRNAW FNFVIHGYHL GGPIVKRNFS 720 FLLTIAYNSP PLASEFPANN KELSLEMNTI LRRGSSNENI KQQKQQITEY FNTNIVQYRT 780 TSSSKIMFLA AAVLLETIRC EAGDCSKTLL YFSDPSILSG SIEKCIAVLS VSMIRKYARL 840 IQKGNDAIFN SKMIAQQLNN LLLCLSHREP TLQDAAFHAC EIFIRSIPSS LCHHLSLYTL 900 LDMLTALFDS ILDSEAHKFE PRYEFKLKHS KTTILVPSSS SWRATTLSRL HKSAKEWVRI 960 LLNRSNQDTK ILLQSYISDL GEYSRLNSVE FGVSFAMDMA GLILPADKEL SRLTYYGPEK 1020 PNTISGFISL HSWRSKYLFD TAITSSPEDI KRQIGISTQN IRKNLTLGNK IITKDVTDFL 1080 DMATALLILG NGAPASLIYD IVHIPFEVFT SASLKIATNV WLTIITEKPE VAHLLLVEVC 1140 YCWMRSIDDN IGLYSRDHDL KGEEYQKMEY SPYDKAGINR DAKNASQAMQ PHLHVIKFFA 1200 SHFEGTLFQS DFLLKIFTKC ALYGIKNLYK ASLHPFARMI RHELLLFATL VLNASYKQGS 1260 KYMGRLSQEI TNGALSWFKR PVAWPFGSNE LKIKADLSVT RDLFLQLNKL SSLMSRHCGK 1320 DYKILNYFLA SEIQQIQTWL TPTEKIEGAD SNELTSDIVE ATFAKDPTLA INLLQRCYSK 1380 KAEDVLVGLV AKHALMCVGS PSALDLFIKG SHLSSKKDLH ATLYWAPVSP LKSINLFLPE 1440 WQGNSFILQF SIYSLESQDV NLAFFYVPQI VQCLRYDKTG YVERLILDTA KISVLFSHQI 1500 IWNMLANCYK DDEGIQEDEI KPTLDRIRER MVSSFSQSHR DFYEREFEFF DEVTGISGKL 1560 KPYIKKSKAE KKHKIDEEMS KIEVKPDVYL PSNPDGVVID IDRKSGKPLQ SHAKAPFMAT 1620 FKIKKDVKDP LTGKNKEVEK WQAAIFKVGD DCRQDVLALQ LISLFRTIWS SIGLDVYVFP 1680 YRVTATAPGC GVIDVLPNSV SRDMLGREAV NGLYEYFTSK FGNESTIEFQ NARNNFVKSL 1740 AGYSVISYLL QFKDRHNGNI MYDDQGHCLH IDFGFIFDIV PGGIKFEAVP FKLTKEMVKV 1800 MGGSPQTPAY LDFEELCIKA YLAARPHVEA IIECVNPMLG SGLPCFKGHK TIRNLRARFQ 1860 PQKTDHEAAL YMKALIRKSY ESIFTKGYDE FQRLTNGIPY 1900 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:SGD. GO:0005886; C:plasma membrane; IDA:SGD. GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IDA:SGD. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |