CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042777
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Guanine nucleotide exchange factor VAV3 
Protein Synonyms/Alias
  
Gene Name
 VAV3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
196SCCLAEIKQTEEKYTubiquitination[1]
306LKLEECSKRANNGKFubiquitination[1]
312SKRANNGKFTLRDLLubiquitination[1]
569SGEQGTLKLPEKRTNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 616 AA 
Protein Sequence
XCAQWLIHCK VLPTNHRVTW DSAQVFDLAQ TLRDGVLLCQ LLNNLRAHSI NLKEINLRPQ 60
MSQFLCLKNI RTFLTACCET FGMRKSELFE AFDLFDVRDF GKVIETLSRL SRTPIALATG 120
IRPFPTEESI NDEDIYKGLP DLIDETLVED EEDLYDCVYG EDEGGEVYED LMKAEEAHQP 180
KCPENDIRSC CLAEIKQTEE KYTETLESIE KYFMAPLKRF LTAAEFDSVF INIPELVKLH 240
RNLMQEIHDS IVNKNDQNLY QVFINYKERL VIYGQYCSGV ESAISSLDYI SKTKEDVKLK 300
LEECSKRANN GKFTLRDLLV VPMQRVLKYH LLLQELVKHT TDPTEKANLK LALDAMKDLA 360
QYVNEVKRDN ETLREIKQFQ LSIENLNQPV LLFGRPQGDG EIRITTLDKH TKQERHIFLF 420
DLAVIVCKRK GDNYEMKEII DLQQYKIANN PTTDKENKKW SYGFYLIHTQ GQNGLEFYCK 480
TKDLKKKWLE QFEMALSNIR PDYADSNFHD FKMHTFTRVT SCKVCQMLLR GTFYQGYLCF 540
KCGARAHKEC LGRVDNCGRV NSGEQGTLKL PEKRTNGLRR TPKQVDPDVP CLLHFFISMA 600
PATRSIVKSQ KKNKKF 616 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR022613; CAMSAP_CH.
 IPR001715; CH-domain.
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR003096; SM22_calponin. 
Pfam
 PF00130; C1_1
 PF11971; CAMSAP_CH
 PF00169; PH
 PF00621; RhoGEF 
SMART
 SM00109; C1
 SM00033; CH
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS50021; CH
 PS00741; DH_1
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS
 PR00888; SM22CALPONIN.