| Tag | Content |
|---|
| CPLM ID | CPLM-011336 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sterol regulatory element-binding protein ECM22 |
Protein Synonyms/Alias | Extracellular mutant protein 22 |
Gene Name | ECM22 |
Gene Synonyms/Alias | YLR228C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 88 | RKDSSSSKFASAVHD | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Transcription factor involved in sterol uptake and regulation of sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters and regulates transcription of ERG2 and ERG3 in response to sterol levels. Seems to be involved in activation of DAN2 and DAN3 cell wall mannoproteins. |
Sequence Annotation | DNA_BIND 43 73 Zn(2)-C6 fungal-type.
MOD_RES 431 431 Phosphoserine.
MOD_RES 445 445 Phosphoserine.
MOD_RES 464 464 Phosphoserine. |
Keyword | Activator; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 814 AA |
Protein Sequence | MTSDDGNAGQ EREKDAELIE VGGKKVSKTS TGKRKFHNKS KTGCDNCKRR RVKCDEGKPF 60
CKKCTNMKLD CVYSPIQPRR RKDSSSSKFA SAVHDRVGKK NLSDNAIMLQ QQQQQLHHQQ 120
EQQFRQQQQV QLQQQLLPHV GTDEQSNSPN SVPPSVSNNM ENLLLPHLLA SLVNNTSNST 180
NSSANGAEAH NNITQTAPSS MINNNHPNMA LPGNSPLSIP ITPSFQSTAM NLSSSLNGLL 240
SPGRLNSVTN GLQQPQLQQQ NQQIPQQQGT QSPFSNIPFD QLAQLNKMGL NFNMKSFNTL 300
FPYGAANGMA SEFQELFGLG KFATSNNRAI KVSTAEEALA NMQQEQEDKN KQFTKNPLDN 360
TKTDAVNSGN NPLNGNENKV TASDILSHNK NLIIDNTGLT ISPPHTLSKP SIDQNIASPS 420
TGVSNVTSTK SLLSIPDNRT ALGNSPTLKT SPMGDLLSNS EALSPRSSNS HTQQQSSPHS 480
NASSASRLVP ELVGLSRKSN LNLIDLKLFH HYCTDVWHTI TEAGISGPEV WSTYIPDLAF 540
HFPFLMHTIL AFSATHLSRT EAGLDNYVSS HRLEALRLLR EAVLEISDDN TDALVASALI 600
LILDSLANAS SSSPTAWIFH VKGAVTILTA VWPLSETSKF YNLISVDLSD LGEAVINQSN 660
HNNDNDNSNN GDGNNNNTIS ELVCFDESIA DLYPVEIDSP YLITLAYLDK LHREKNQLDF 720
MLRVFSFPAL LDRTFLALLM TGDLGAMRIM RSYYTLLRGY TTEIKDKVWF LDSVSQVLPQ 780
DVDEYSGGGG MHMMLDFLGG GLPSMTTTNF SAFM 814 |
Gene Ontology | GO:0016020; C:membrane; IDA:SGD. GO:0005634; C:nucleus; IC:SGD. GO:0048471; C:perinuclear region of cytoplasm; IDA:SGD. GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:SGD. GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:SGD. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0035961; P:positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter; IMP:SGD. GO:0035969; P:positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter; IGI:SGD. |
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