CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005967
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homeobox protein Hox-A11 
Protein Synonyms/Alias
 Homeobox protein Hox-1I 
Gene Name
 HOXA11 
Gene Synonyms/Alias
 HOX1I 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
72YAIEPATKWHPRGNLubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. 
Sequence Annotation
 DNA_BIND 241 300 Homeobox.  
Keyword
 Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 313 AA 
Protein Sequence
MDFDERGPCS SNMYLPSCTY YVSGPDFSSL PSFLPQTPSS RPMTYSYSSN LPQVQPVREV 60
TFREYAIEPA TKWHPRGNLA HCYSAEELVH RDCLQAPSAA GVPGDVLAKS SANVYHHPTP 120
AVSSNFYSTV GRNGVLPQAF DQFFETAYGT PENLASSDYP GDKSAEKGPP AATATSAAAA 180
AAATGAPATS SSDSGGGGGC RETAAAAEEK ERRRRPESSS SPESSSGHTE DKAGGSSGQR 240
TRKKRCPYTK YQIRELEREF FFSVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKIN 300
RDRLQYYSAN PLL 313 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0032993; C:protein-DNA complex; ISS:UniProtKB.
 GO:0005667; C:transcription factor complex; ISS:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
 GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; ISS:UniProtKB.
 GO:0048589; P:developmental growth; ISS:UniProtKB.
 GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0030326; P:embryonic limb morphogenesis; ISS:UniProtKB.
 GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Compara.
 GO:0007501; P:mesodermal cell fate specification; ISS:UniProtKB.
 GO:0001656; P:metanephros development; IEA:Compara.
 GO:0001759; P:organ induction; IEA:Compara.
 GO:0010720; P:positive regulation of cell development; ISS:UniProtKB.
 GO:0032332; P:positive regulation of chondrocyte differentiation; ISS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0009954; P:proximal/distal pattern formation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR021918; DUF3528.
 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 
Pfam
 PF12045; DUF3528
 PF00046; Homeobox 
SMART
 SM00389; HOX 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 
PRINTS
 PR00024; HOMEOBOX.