UniProt Accession

 GCH1_ECOLI; P0A6T5; P27511; Q2MAS6 

Genbank Protein ID

 X63910; U00007; U00096; AP009048 

Genbank Nucleotide ID

 CAA45365.1; AAA60535.1; AAC75214.1; BAE76630.1 

Protein Name

 GTP cyclohydrolase 1 

Protein Synonyms/Alias

 GTP cyclohydrolase I; GTP-CH-I 

Gene Name

 folE 

Gene Synonyms/Alias

 b2153; JW2140 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
6	**MPSLSKEAALVHE	acetylation	[1, 2]
69	ETPHRIAKMYVDEIF	acetylation	[2]
86	LDYANFPKITLIENK	acetylation	[2]
93	KITLIENKMKVDEMV	acetylation	[2]
95	TLIENKMKVDEMVTV	acetylation	[2]
129	ATVAYIPKDSVIGLS	acetylation	[2]
137	DSVIGLSKINRIVQF	acetylation	[1, 2, 3]
205	TSLGGLFKSSQNTRH	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [3] The diversity of lysine-acetylated proteins in Escherichia coli.
 Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG.
 J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [PMID: 18852508] 

Functional Description

  

Sequence Annotation

 METAL 111 111 Zinc.
 METAL 114 114 Zinc.
 METAL 182 182 Zinc.  

Keyword

 3D-structure; Allosteric enzyme; Complete proteome; Direct protein sequencing; GTP-binding; Hydrolase; Metal-binding; Nucleotide-binding; One-carbon metabolism; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:EcoliWiki.
 GO:0043234; C:protein complex; IDA:EcoliWiki.
 GO:0005525; F:GTP binding; IDA:EcoliWiki.
 GO:0003934; F:GTP cyclohydrolase I activity; IDA:EcoCyc.
 GO:0008270; F:zinc ion binding; IDA:EcoCyc.
 GO:0035998; P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006730; P:one-carbon metabolic process; IEA:HAMAP.
 GO:0008616; P:queuosine biosynthetic process; IMP:EcoCyc.
 GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:HAMAP. 

Interpro

 IPR001474; GTP_CycHdrlase_I.
 IPR020602; GTP_CycHdrlase_I/CN_OxRdtase.
 IPR018234; GTP_CycHdrlase_I_CS. 

Pfam

 PF01227; GTP_cyclohydroI 

SMART

  

PROSITE

 PS00859; GTP_CYCLOHYDROL_1_1
 PS00860; GTP_CYCLOHYDROL_1_2 

PRINTS