UniProt Accession

 D6RAP6_HUMAN; D6RAP6 

Genbank Protein ID

 AC108218; AC110812 

Genbank Nucleotide ID

  

Protein Name

 Anaphase-promoting complex subunit 4 

Protein Synonyms/Alias

  

Gene Name

 ANAPC4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
89	FALADTKKIVLCDVE	ubiquitination	[1]
147	PKLPTLPKNYSNTSK	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 162 AA 

Protein Sequence

Gene Ontology

 GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
 GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
 GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:InterPro. 

Interpro

 IPR024789; APC4.
 IPR024977; Apc4_WD40_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF12894; Apc4_WD40 

SMART

  

PROSITE

  

PRINTS