CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030763
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase ULK3 
Protein Synonyms/Alias
 cDNA FLJ50476, weakly similar to Serine/threonine-protein kinase ULK1 (EC2.7.11.1) 
Gene Name
 ULK3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
64VAKKSLNKASVENLLubiquitination[1]
78LTEIEILKGIRHPHIubiquitination[1]
150NISHLDLKPQNILLSubiquitination[1]
181HMSPWDEKHVLRGSPubiquitination[1]
235SFSELEEKIRSNRVIubiquitination[1]
305LVVQAVKKDQEGDSAubiquitination[1]
344RKEAIKAKVGQYVSRubiquitination[1, 2]
356VSRAEELKAIVSSSNubiquitination[1, 2]
469WEADTLDKEGLSESVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 483 AA 
Protein Sequence
MQRNGSASRG LEKTRLRLCR EARIPESAFL TGLTRESWEA RCWCAKDTRE VVAIKCVAKK 60
SLNKASVENL LTEIEILKGI RHPHIVQLKD FQWDSDNIYL IMEFCAGGDL SRFIHTRRIL 120
PEKVARVFMQ QLASALQFLH ERNISHLDLK PQNILLSSLE KPHLKLADFG FAQHMSPWDE 180
KHVLRGSPLY MAPEMVCQRQ YDARVDLWSM GVILYEALFG QPPFASRSFS ELEEKIRSNR 240
VIELPLRPLL SRDCRDLLQR LLERDPSRRI SFQDFFAHPW VDLEHMPSGE SLGRATALVV 300
QAVKKDQEGD SAAALSLYCK ALDFFVPALH YEVDAQRKEA IKAKVGQYVS RAEELKAIVS 360
SSNQALLRQG TSARDLLREM ARDKPRLLAA LEVASAAMAK EEAAGGEQDA LDLYQHSLGE 420
LLLLLAAEPP GRRRELLHTE VQNLMARAEY LKEQVKMRES RWEADTLDKE GLSESVRSSC 480
TLQ 483 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR007330; MIT.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF04212; MIT
 PF00069; Pkinase 
SMART
 SM00745; MIT
 SM00220; S_TKc 
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS