CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037331
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Beta-glucuronidase 
Protein Synonyms/Alias
  
Gene Name
 GUSB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
39ESPSRECKELDGLWSubiquitination[1, 2, 3]
213EDADIRGKGFDWPLLubiquitination[4]
222FDWPLLVKDFNLLRWubiquitination[4]
495RYPHSVAKSQCLENSubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 505 AA 
Protein Sequence
MARGSAVAWA ALGPLLWGCA LGLQGGMLYP QESPSRECKE LDGLWSFRAD FSDNRRRGFE 60
EQWYRRPLWE SGPTVDMPVP SSFNDISQDW RLRHFVGWVW YEREVILPER WTQDLRTRVV 120
LRIGSAHSYA IVWVNGVDTL EHEGGYLPFE ADISNLVQVQ LTAQTSLGPV SDFYTLPVGI 180
RTVAVTKSQF LINGKPFYFH GVNKHEDADI RGKGFDWPLL VKDFNLLRWL GANAFRTSHY 240
PYAEEVMQMC DRYGIVVIDE CPGVGLALPQ FFNNVSLHHH MQVMEEVVRR DKNHPAVVMW 300
SVANEPASHL ESAGYYLKMV IAHTKSLDPS RPVTFVSNSN YAADKGAPYV DVICLNSYYS 360
WYHDYGHLEL IQLQLATQFE NWYKKYQKPI IQSEYGAETI AGFHQDPPLM FTEEYQKSLL 420
EQYHLGLDQK RRKYVVGELI WNFADFMTEQ SPTRVLGNKK GIFTRQRQPK SAAFLLRERY 480
WKIANETRYP HSVAKSQCLE NSLFT 505 
Gene Ontology
 GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. 
Interpro
 IPR008979; Galactose-bd-like.
 IPR023232; Glyco_hydro_2_AS.
 IPR023230; Glyco_hydro_2_CS.
 IPR006104; Glyco_hydro_2_N.
 IPR006103; Glyco_hydro_2_TIM.
 IPR013781; Glyco_hydro_catalytic_dom.
 IPR017853; Glycoside_hydrolase_SF. 
Pfam
 PF02836; Glyco_hydro_2_C
 PF02837; Glyco_hydro_2_N 
SMART
  
PROSITE
 PS00719; GLYCOSYL_HYDROL_F2_1
 PS00608; GLYCOSYL_HYDROL_F2_2 
PRINTS