| Tag | Content |
|---|
| CPLM ID | CPLM-020828 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | SUN domain-containing protein 1 |
Protein Synonyms/Alias | Protein unc-84 homolog A; Sad1/unc-84 protein-like 1 |
Gene Name | Sun1 |
Gene Synonyms/Alias | Unc84a |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 160 | LDDDGDLKGGNKAAT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non- coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). |
Sequence Annotation | DOMAIN 751 912 SUN.
REGION 1 139 LMNA-binding (By similarity).
REGION 209 399 SYNE2-binding (By similarity).
REGION 310 399 EMD-binding (By similarity).
MOD_RES 48 48 Phosphoserine.
MOD_RES 52 52 Phosphoserine.
MOD_RES 139 139 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Membrane; Nucleus; Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 913 AA |
Protein Sequence | MDFSRLHTYT PPQCVPENTG YTYALSSSYS SDALDFETEH KLEPVFDSPR MSRRSLRLVT 60
TASYSSGDSQ AIDSHISTSR ATPAKGRETR TVKQRRSASK PAFSINHLSG KGLSSSTSHD 120
SSCSLRSATV LRHPVLDESL IREQTKVDHF WGLDDDGDLK GGNKAATQGN GELAAEVASS 180
NGYTCRDCRM LSARTDALTA HSAIHGTTSR VYSRDRTLKP RGVSFYLDRT LWLAKSTSSS 240
FASFIVQLFQ VVLMKLNFET YKLKGYESRA YESQSYETKS HESEAHLGHC GRMTAGELSR 300
VDGESLCDDC KGKKHLEIHT ATHSQLPQPH RVAGAMGRLC IYTGDLLVQA LRRTRAAGWS 360
VAEAVWSVLW LAVSAPGKAA SGTFWWLGSG WYQFVTLISW LNVFLLTRCL RNICKVFVLL 420
LPLLLLLGAG VSLWGQGNFF SLLPVLNWTA MQPTQRVDDS KGMHRPGPLP PSPPPKVDHK 480
ASQWPQESDM GQKVASLSAQ CHNHDERLAE LTVLLQKLQI RVDQVDDGRE GLSLWVKNVV 540
GQHLQEMGTI EPPDAKTDFM TFHHDHEVRL SNLEDVLRKL TEKSEAIQKE LEETKLKAGS 600
RDEEQPLLDR VQHLELELNL LKSQLSDWQH LKTSCEQAGA RIQETVQLMF SEDQQGGSLE 660
WLLEKLSSRF VSKDELQVLL HDLELKLLQN ITHHITVTGQ APTSEAIVSA VNQAGISGIT 720
EAQAHIIVNN ALKLYSQDKT GMVDFALESG GGSILSTRCS ETYETKTALL SLFGVPLWYF 780
SQSPRVVIQP DIYPGNCWAF KGSQGYLVVR LSMKIYPTTF TMEHIPKTLS PTGNISSAPK 840
DFAVYGLETE YQEEGQPLGR FTYDQEGDSL QMFHTLERPD QAFQIVELRV LSNWGHPEYT 900
CLYRFRVHGE PIQ 913 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |