CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001371
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aromatic-L-amino-acid decarboxylase 
Protein Synonyms/Alias
 AADC; DOPA decarboxylase; DDC 
Gene Name
 Ddc 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
205AGLIGGIKLKAVPSDubiquitination[1]
207LIGGIKLKAVPSDGNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. 
Sequence Annotation
 REPEAT 58 115 1.
 REPEAT 118 178 2.
 REGION 58 178 2 X approximate tandem repeats.
 BINDING 82 82 Substrate (By similarity).
 BINDING 148 148 PLP; via amide nitrogen (By similarity).
 BINDING 149 149 PLP (By similarity).
 BINDING 192 192 Substrate (By similarity).
 BINDING 246 246 PLP; via carbonyl oxygen (By similarity).
 BINDING 300 300 PLP (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 303 303 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Acetylation; Catecholamine biosynthesis; Complete proteome; Decarboxylase; Lyase; Pyridoxal phosphate; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 480 AA 
Protein Sequence
MDSREFRRRG KEMVDYIADY LDGIEGRPVY PDVEPGYLRP LIPATAPQEP ETYEDIIKDI 60
EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC IGFSWAASPA CTELETVMMD 120
WLGKMLELPE AFLAGRAGEG GGVIQGSASE ATLVALLAAR TKVIRQLQAA SPEFTQAAIM 180
EKLVAYTSDQ AHSSVERAGL IGGIKLKAVP SDGNFSMRAS ALREALERDK AAGLIPFFVV 240
ATLGTTSCCS FDNLLEVGPI CNQEGVWLHI DAAYAGSAFI CPEFRYLLNG VEFADSFNFN 300
PHKWLLVNFD CSAMWVKRRT DLTGAFNMDP VYLKHSHQDS GFITDYRHWQ IPLGRRFRSL 360
KMWFVFRMYG VKGLQAYIRK HVELSHEFES LVRQDPRFEI CTEVILGLVC FRLKGSNELN 420
ETLLQRINSA KKIHLVPCRL RDKFVLRFAV CARTVESAHV QLAWEHISDL ASSVLRAEKE 480 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0016597; F:amino acid binding; IEA:Compara.
 GO:0004058; F:aromatic-L-amino-acid decarboxylase activity; IEA:EC.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
 GO:0071312; P:cellular response to alkaloid; IEA:Compara.
 GO:0035690; P:cellular response to drug; IEA:Compara.
 GO:0071363; P:cellular response to growth factor stimulus; IEA:Compara.
 GO:0007623; P:circadian rhythm; IEA:Compara.
 GO:0042416; P:dopamine biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0033076; P:isoquinoline alkaloid metabolic process; IEA:Compara.
 GO:0010259; P:multicellular organismal aging; IEA:Compara.
 GO:0052314; P:phytoalexin metabolic process; IEA:Compara.
 GO:0046684; P:response to pyrethroid; IEA:Compara.
 GO:0009636; P:response to toxic substance; IDA:MGI.
 GO:0042427; P:serotonin biosynthetic process; IEA:Compara.
 GO:0015842; P:synaptic vesicle amine transport; IEA:Compara. 
Interpro
 IPR010977; Aromatic_deC.
 IPR002129; PyrdxlP-dep_de-COase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR021115; Pyridoxal-P_BS. 
Pfam
 PF00282; Pyridoxal_deC 
SMART
  
PROSITE
 PS00392; DDC_GAD_HDC_YDC 
PRINTS
 PR00800; YHDCRBOXLASE.