CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027605
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysine--tRNA ligase 
Protein Synonyms/Alias
 Lysyl-tRNA synthetase 
Gene Name
 Aats-lys 
Gene Synonyms/Alias
 CG12141; Dmel_CG12141 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
93SLEDFIAKYENSLKEacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; Complete proteome; Ligase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 574 AA 
Protein Sequence
MAAASGELSK NELKRRLKAE QKAKEKAEKA AAAPAENTAG KKKSSAAEEE EISPNEYFKL 60
RSAAVQELKR SPATDPYPHK FHVSSSLEDF IAKYENSLKE GETLENVKLS VAGRVHAIRE 120
SGAKLIFYDL RGEGVKVQVM ASAKSYKSEA DFEIDTSKLR RGDIIGVVGH PGKTKKGELS 180
VMPSEIKLLS PCLHMLPHLH FGLKDKETRY RQRYLDLILN NNVREKFQIR AKIISYVRQF 240
LDRLGFLEIE TPMMNMIAGG ATAKPFVTHH NDLKMDLFMR IAPELYHKML VVGGLDRVYE 300
IGRQFRNEGI DLTHNPEFTT CEFYMAYADY ADIMDITEQL VSGMVKAIRG SYKVIYHPEG 360
PEGPEQELDF TPPFKRVSMI KTLEEKLQVK FPAADTFNSP ETNQFLSQLC AKHQVECPAP 420
RTTARLLDKL VGEFIEEFCV NPTFICEHPQ IMSPLAKYHR SIPGLTERFE LFVAKKEICN 480
AYTELNDPVV QRERFEQQAS DKAAGDDEAQ LVDENFCTSL EYGLPPTGGF GMGIDRLAMF 540
LTDSNNIKEV LLFPAMKPED ANRTAAETAP TAQQ 574 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004824; F:lysine-tRNA ligase activity; IEA:EC.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0006430; P:lysyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR004364; aa-tRNA-synt_II.
 IPR018150; aa-tRNA-synt_II-like.
 IPR006195; aa-tRNA-synth_II.
 IPR002313; Lys-tRNA-ligase_II.
 IPR018149; Lys-tRNA-synth_II_C.
 IPR012340; NA-bd_OB-fold.
 IPR004365; NA-bd_OB_tRNA-helicase. 
Pfam
 PF00152; tRNA-synt_2
 PF01336; tRNA_anti 
SMART
  
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS
 PR00982; TRNASYNTHLYS.