CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004028
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-complex protein 1 subunit alpha 
Protein Synonyms/Alias
 TCP-1-alpha; CCT-alpha 
Gene Name
 T-cp1 
Gene Synonyms/Alias
 CCT-1; Tcp-1; CG5374 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
196GQAAYSIKAINVLKAacetylation[1]
320RVKKSDLKIIAKATGacetylation[1]
403HDALCVVKRVLESKKacetylation[1]
469DATDLVAKLRSYHNSacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. 
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 557 AA 
Protein Sequence
MSTLASPLSI AGTRQSGASV RTQNVMAALS ISNIVKSSLG PVGLDKMLVD DIGDVTVTND 60
GATILRLLEV EHPAAKVLVE LAQLQDEEVG DGTTSVVILA AELLKNADEL VKQKIHPTSI 120
ISGYRIACKE ACKYISEHLT APVDELGRDS LINIAKTSMS SKIIGADAEF FSAMVVDAAQ 180
SVKITDPRGQ AAYSIKAINV LKAHGKSARE SVLIPGYALN CTIASQQMPK KIVNAKIACL 240
DFSLQKTKMK MGVQVLINDP DKLEAIRARE LDITKERINM ILGTGVNVVL VSGGVDDLCM 300
KYFVEAGAMA VRRVKKSDLK IIAKATGAAF ITSLTNMDGE ESFDASMVGE AAEVAQERIC 360
DDELILIKGT KARAAASIIL RGPNDFYCDE MERSVHDALC VVKRVLESKK VVAGGGCVEA 420
ALSIYLENFA TSLASREQLA IAEFAKSLLV IPKTLSVNAA KDATDLVAKL RSYHNSSQTK 480
PERSDLKWTG LDLIEGVVRD NKKAGVLEPA MSKIKSLKFA TEAAITILRI DDMIKLNPED 540
KSGKSYADAC AAGELDG 557 
Gene Ontology
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; NAS:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008553; F:hydrogen-exporting ATPase activity, phosphorylative mechanism; NAS:FlyBase.
 GO:0007052; P:mitotic spindle organization; IMP:FlyBase.
 GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR012715; Chap_CCT_alpha.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00750; TCP1_1
 PS00751; TCP1_2
 PS00995; TCP1_3 
PRINTS
 PR00304; TCOMPLEXTCP1.