| Tag | Content |
|---|
| CPLM ID | CPLM-018683 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | U4/U6 small nuclear ribonucleoprotein Prp3 |
Protein Synonyms/Alias | Pre-mRNA-splicing factor 3 |
Gene Name | Prpf3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 495 | EAVQDPTKVEAHVRA | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (By similarity). |
Sequence Annotation | DOMAIN 1 87 PWI.
MOD_RES 164 164 Phosphoserine (By similarity).
MOD_RES 619 619 Phosphoserine. |
Keyword | Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 683 AA |
Protein Sequence | MALSKRELDE LKPWIEKTVK RVLGFSEPTV VTAALNCVGK GMDKKKAADH LKPFLDDSTL 60
RFVDKLFEAV EEGRSSRHSK SSSDRSRKRE LKEVFGDDSE ISKESSGVKK RRIPRFEEVE 120
EEPEVIPGPP SESPGMLTKL QIKQMMEAAT RQIEERKKQL SFISPPAPQP KTPSSSQPER 180
LPIGNTIQPS QAATFMNDAI EKARKAAELQ ARIQAQLALK PGLIGNANMV GLANLHAMGI 240
APPKVELKDQ TKPTPLILDE QGRTVDATGK EVELTHRMPT LKANIRAVKR EQFKQQLKEK 300
PSEDMESNTF FDPRVSIAPS QRQRRTFKFH DKGKFEKIAQ RLRTKAQLEK LQAEISQAAR 360
KTGIHTSTRL ALIAPKKELK EGDIPEIEWW DSYIIPNGFD LTEENPKRED YFGITNLVEH 420
PAQLNPPVDN DTPVTLGVYL TKKEQKKLRR QTRREAQKEL QEKVRLGLTP PPEPKVRISN 480
LMRVLGTEAV QDPTKVEAHV RAQMAKRQKA HEEANAARKL TAEQRKVKKI KKLKEDISQG 540
VHISVYRVRN LSNPAKKFKI EANAGQLYLT GVVVLHKDVN VVVVEGGPKA QKKFKRLMLH 600
RIKWDEQTSN TKGDDDEESD EEAVKKTNKC VLVWEGTAKD RSFGEMKFKQ CPTENMAREH 660
FKKHGAEHYW DLALSESVLE STD 683 |
Gene Ontology | GO:0015030; C:Cajal body; IEA:Compara. GO:0005737; C:cytoplasm; IEA:Compara. GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW. GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:InterPro. GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |