CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023267
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Conserved oligomeric Golgi complex subunit 5 
Protein Synonyms/Alias
 COG complex subunit 5; 13S Golgi transport complex 90 kDa subunit; GTC-90; Component of oligomeric Golgi complex 5; Golgi transport complex 1 
Gene Name
 COG5 
Gene Synonyms/Alias
 GOLTC1; GTC90 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
94VIAEQLAKLAQGISQacetylation[1]
158KIVEPYNKIVARTAQubiquitination[2]
465QDIFIPKKPDYDPEKubiquitination[2]
475YDPEKALKDSLQPYEubiquitination[2]
488YEAAYLSKSLSRLFDubiquitination[2, 3, 4]
544AVSKNVAKTIQLYSVubiquitination[2]
698RPLGEGGKMRLAADFubiquitination[2]
724RRVSDLGKSYRMLRSubiquitination[2, 5]
771TRAPAELKSPFQRAEubiquitination[2, 4]
795LDDHPSEKDRLLLIRubiquitination[2, 4, 5]
818SVRSREGKEFAPVYPubiquitination[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Required for normal Golgi function (By similarity). 
Sequence Annotation
 MOD_RES 197 197 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Congenital disorder of glycosylation; Cytoplasm; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 839 AA 
Protein Sequence
MGWVGGRRRD SASPPGRSRS AADDINPAPA NMEGGGGSVA VAGLGARGSG AAAATVRELL 60
QDGCYSDFLN EDFDVKTYTS QSIHQAVIAE QLAKLAQGIS QLDRELHLQV VARHEDLLAQ 120
ATGIESLEGV LQMMQTRIGA LQGAVDRIKA KIVEPYNKIV ARTAQLARLQ VACDLLRRII 180
RILNLSKRLQ GQLQGGSREI TKAAQSLNEL DYLSQGIDLS GIEVIENDLL FIARARLEVE 240
NQAKRLLEQG LETQNPTQVG TALQVFYNLG TLKDTITSVV DGYCATLEEN INSALDIKVL 300
TQPSQSAVRG GPGRSTMPTP GNTAALRASF WTNMEKLMDH IYAVCGQVQH LQKVLAKKRD 360
PVSHICFIEE IVKDGQPEIF YTFWNSVTQA LSSQFHMATN SSMFLKQAFE GEYPKLLRLY 420
NDLWKRLQQY SQHIQGNFNA SGTTDLYVDL QHMEDDAQDI FIPKKPDYDP EKALKDSLQP 480
YEAAYLSKSL SRLFDPINLV FPPGGRNPPS SDELDGIIKT IASELNVAAV DTNLTLAVSK 540
NVAKTIQLYS VKSEQLLSTQ GDASQVIGPL TEGQRRNVAV VNSLYKLHQS VTKAIHALME 600
NAVQPLLTSV GDAIEAIIIT MHQEDFSGSL SSSGKPDVPC SLYMKELQGF IARVMSDYFK 660
HFECLDFVFD NTEAIAQRAV ELFIRHASLI RPLGEGGKMR LAADFAQMEL AVGPFCRRVS 720
DLGKSYRMLR SFRPLLFQAS EHVASSPALG DVIPFSIIIQ FLFTRAPAEL KSPFQRAEWS 780
HTRFSQWLDD HPSEKDRLLL IRGALEAYVQ SVRSREGKEF APVYPIMVQL LQKAMSALQ 839 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0017119; C:Golgi transport complex; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0006891; P:intra-Golgi vesicle-mediated transport; NAS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR019465; Cog5. 
Pfam
 PF10392; COG5 
SMART
  
PROSITE
  
PRINTS