| Tag | Content |
|---|
| CPLM ID | CPLM-017874 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Src-like-adapter 2 |
Protein Synonyms/Alias | Src-like adapter protein 2; SLAP-2 |
Gene Name | Sla2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 201 | KLGPLPGKDTPPPVT | ubiquitination | [1] |
|
Reference | [1] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A. Nature. 2012 Nov 22;491(7425):618-21. [ PMID: 23086144] |
Functional Description | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. |
Sequence Annotation | DOMAIN 31 91 SH3.
DOMAIN 93 190 SH2.
REGION 190 259 SLA C-terminal.
LIPID 2 2 N-myristoyl glycine. |
Keyword | Adaptive immunity; Alternative initiation; Cell membrane; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Endosome; Immunity; Lipoprotein; Membrane; Myristate; Phosphoprotein; Reference proteome; SH2 domain; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 259 AA |
Protein Sequence | MGSLSSRGKT SSPSPSSSGP DQEPVSMQPE RHKVTAVALG SFPAGEQARL SLRLGEPLTI 60
ISEDGDWWTV QSEVSGREYH MPSVYVAKVA HGWLYEGLSR EKAEELLLLP GNPGGAFLIR 120
ESQTRRGCYS LSVRLSRPAS WDRIRHYRIQ RLDNGWLYIS PRLTFPSLHA LVEHYSELAD 180
GICCPLREPC VLQKLGPLPG KDTPPPVTVP TSSLNWKKLD RSLLFLEAPA SGEASLLSEG 240
LRESLSSYIS LAEDPLDDA 259 |
Gene Ontology | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI. GO:0005770; C:late endosome; IDA:MGI. GO:0005886; C:plasma membrane; IDA:MGI. GO:0047485; F:protein N-terminus binding; ISS:UniProtKB. GO:0005070; F:SH3/SH2 adaptor activity; ISS:UniProtKB. GO:0050849; P:negative regulation of calcium-mediated signaling; IEA:Compara. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB. GO:0042110; P:T cell activation; IDA:MGI. |
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Pfam | |
SMART | |
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PRINTS | |