UniProt Accession

 F8VR40_HUMAN; F8VR40 

Genbank Protein ID

 AC093012 

Genbank Nucleotide ID

  

Protein Name

 Interleukin-1 receptor-associated kinase 4 

Protein Synonyms/Alias

  

Gene Name

 IRAK4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
3	*****MNKPITPSTY	ubiquitination	[1]
34	DPQEGWKKLAVAIKK	acetylation	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 89 AA 

Protein Sequence

Gene Ontology

 GO:0001816; P:cytokine production; IEA:Compara.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0007254; P:JNK cascade; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. 

Interpro

 IPR011029; DEATH-like_dom. 

Pfam

  

SMART

  

PROSITE

  

PRINTS