| Tag | Content |
|---|
| CPLM ID | CPLM-000595 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rab GTPase-binding effector protein 1 |
Protein Synonyms/Alias | Rabaptin-5; Rabaptin-5alpha |
Gene Name | Rabep1 |
Gene Synonyms/Alias | Rab5ep; Rabpt5; Rabpt5a |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 107 | QEAIDEVKRQWREEV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A (By similarity). |
Sequence Annotation | MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 282 282 N6-acetyllysine (By similarity).
MOD_RES 407 407 Phosphoserine (By similarity).
MOD_RES 410 410 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Endocytosis; Endosome; Phosphoprotein; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 862 AA |
Protein Sequence | MAQPGPAPQP DVSLQQRVAE LEKINAEFLR AQQQLEQEFN QKRAKFKELY LAKEEDLKRQ 60
NAVLQAAQDD LGHLRTQLWE AQAEMENIKA IATVSENTKQ EAIDEVKRQW REEVASLQAI 120
MKETVRDYEH QFHLRLEQER AQWAQYRESA EREIADLRRR LSEGQEEENL ENEMKKAQED 180
AEKLRSVVMP MEKEIAALKD KLTEAEDKIK ELEASKVKEL NHYLEAEKSC RTDLEMYVAV 240
LNTQKSVLQE DAEKLRKELH EVCHLLEQER QQHNQLKHTW QKANDQFLES QRLLMRDMQR 300
MEIVLTSEQL RQVEELKKKD QEEDEQQRVN KRKDNKKTDT EEEVKIPVVC ALTQEESSTP 360
LSNEEEHLDS THGSVHSLDA DLMLPSGDPF SKSDNDMFKD GLRRAQSTDS LGTSSSLQSK 420
ALGYNYKAKS AGNLDESDFG PLVGADSVSE NFDTVSLGSL QMPSGFMLTK DQERAIKAMT 480
PEQEETASLL SSVTQGMESA YVSPSGYRLV SETEWNLLQK EVHNAGNKLG RRCDMCSNYE 540
KQLQGIQIQE AETRDQVKKL QLMLRQANDQ LEKTMKEKQE LEDFLKQSAE DSSHQISALV 600
LRAQASEVLL EELQQSFSQA KRDVQEQMAV LMQSREQVSE ELVRLQKDND SLQGKHSLHV 660
SLQLAEDFIL PDTVEVLREL VLKYRENIVH VRTAADHMEE KLKAEILFLK EQIQAEQCLK 720
ENLEETLQLE IENCKEEIAS ISSLKAELER IKVEKGQLES TLREKSQQLE SLQEMKVNLE 780
EQLKKETAAK ATVEQLMFEE KNKAQRLQTE LDVSEQVQRD FVKLSQTLQV QLERIRQADS 840
LERIRAILND TKLTDINQLP ET 862 |
Gene Ontology | GO:0005769; C:early endosome; IEA:UniProtKB-SubCell. GO:0030139; C:endocytic vesicle; ISS:UniProtKB. GO:0005768; C:endosome; IDA:MGI. GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell. GO:0005096; F:GTPase activator activity; IEA:InterPro. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0006897; P:endocytosis; IEA:UniProtKB-KW. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |