UniProt Accession

 GSC_MOUSE; Q02591 

Genbank Protein ID

 M85271; Y13149; Y13150 

Genbank Nucleotide ID

 AAA37826.1; CAA73611.1; CAA73612.1 

Protein Name

 Homeobox protein goosecoid 

Protein Synonyms/Alias

  

Gene Name

 Gsc 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
183	ENLFQETKYPDVGTR	sumoylation	[1]
196	TREQLARKVHLREEK	sumoylation	[1]
203	KVHLREEKVEVWFKN	sumoylation	[1]
209	EKVEVWFKNRRAKWR	sumoylation	[1]
214	WFKNRRAKWRRQKRS	sumoylation	[1]
238	KWNKTSSKASPEKRE	sumoylation	[1]

Reference

 [1] Sumoylation differentially regulates Goosecoid-mediated transcriptional repression.
 Izzi L, Narimatsu M, Attisano L.
 Exp Cell Res. 2008 Apr 15;314(7):1585-94. [PMID: 18336814] 

Functional Description

 Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis (By similarity). In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Goosecoid-expressing regions of the gastrulating mouse egg cylinder have organizer-like activity when transplanted into Xenopus embryos. 

Sequence Annotation

 DNA_BIND 160 219 Homeobox.  

Keyword

 Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 256 AA 

Protein Sequence

Gene Ontology

 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0021904; P:dorsal/ventral neural tube patterning; IGI:MGI.
 GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
 GO:0030900; P:forebrain development; IGI:MGI.
 GO:0042474; P:middle ear morphogenesis; IMP:UniProtKB.
 GO:0048644; P:muscle organ morphogenesis; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IMP:MGI.
 GO:0023019; P:signal transduction involved in regulation of gene expression; IDA:MGI. 

Interpro

 IPR017970; Homeobox_CS.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 

Pfam

 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS