CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002537
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine protease inhibitor A3K 
Protein Synonyms/Alias
 Serpin A3K; Contrapsin; SPI-2 
Gene Name
 Serpina3k 
Gene Synonyms/Alias
 Mcm2; Spi2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
93VSLGAKGKTMEEILEubiquitination[1]
155ILAEFHEKTRALYQTubiquitination[1]
235SEFYLDEKRSVKVPMubiquitination[1]
351SGITETKKLSVSQVVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Contrapsin inhibits trypsin-like proteases. 
Sequence Annotation
 REGION 369 394 RCL.
 CARBOHYD 39 39 N-linked (GlcNAc...) (Potential).
 CARBOHYD 105 105 N-linked (GlcNAc...) (Potential).
 CARBOHYD 185 185 N-linked (GlcNAc...).
 CARBOHYD 270 270 N-linked (GlcNAc...).  
Keyword
 Complete proteome; Direct protein sequencing; Glycoprotein; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 418 AA 
Protein Sequence
MAFIVAMGMI LMAGICPAVL CFPDGTKEMD IVFHEHQDNG TQDDSLTLAS VNTDFAFSLY 60
KKLALKNPDT NIVFSPLSIS AALALVSLGA KGKTMEEILE GLKFNLTETP EADIHQGFGN 120
LLQSLSQPED QDQINIGNAM FIEKDLQILA EFHEKTRALY QTEAFTADFQ QPTEAKNLIN 180
DYVSNQTQGM IKELISELDE RTLMVLVNYI YFKGKWKISF DPQDTFESEF YLDEKRSVKV 240
PMMKMKLLTT RHFRDEELSC SVLELKYTGN ASALLILPDQ GRMQQVEASL QPETLRKWRK 300
TLFPSQIEEL NLPKFSIASN YRLEEDVLPE MGIKEVFTEQ ADLSGITETK KLSVSQVVHK 360
AVLDVAETGT EAAAATGVIG GIRKAILPAV HFNRPFLFVI YHTSAQSILF MAKVNNPK 418 
Gene Ontology
 GO:0005576; C:extracellular region; IBA:RefGenome.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome.
 GO:0034097; P:response to cytokine stimulus; IDA:MGI.
 GO:0043434; P:response to peptide hormone stimulus; IDA:MGI. 
Interpro
 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 
Pfam
 PF00079; Serpin 
SMART
 SM00093; SERPIN 
PROSITE
 PS00284; SERPIN 
PRINTS