UniProt Accession

 FADS2_HUMAN; O95864; A8K2M6; Q6MZQ7; Q96H07; Q96SV8; Q9H3G3; Q9Y3X4 

Genbank Protein ID

 AF126799; AF084559; AF108658; AK027513; AK290291; AK074939; CH471076; BC009011; AL050118; BX640945 

Genbank Nucleotide ID

 AAD20018.1; AAG23121.1; AAG43192.1; BAB55167.1; BAF82980.1; BAC11305.1; EAW73975.1; AAH09011.1; CAB43280.1; CAE45971.1 

Protein Name

 Fatty acid desaturase 2 

Protein Synonyms/Alias

 Delta(6) fatty acid desaturase; D6D; Delta(6) desaturase; Delta-6 desaturase 

Gene Name

 FADS2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
62	PDLEFVGKFLKPLLI	ubiquitination	[1]
65	EFVGKFLKPLLIGEL	ubiquitination	[1]
83	EPSQDHGKNSKITED	ubiquitination	[1]
86	QDHGKNSKITEDFRA	ubiquitination	[1]
96	EDFRALRKTAEDMNL	ubiquitination	[1]
229	WQPIEYGKKKLKYLP	ubiquitination	[1]
376	MPRHNLHKIAPLVKS	ubiquitination	[1]
395	HGIEYQEKPLLRALL	ubiquitination	[1]
413	RSLKKSGKLWLDAYL	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum. 

Sequence Annotation

 DOMAIN 18 95 Cytochrome b5 heme-binding.
 MOTIF 180 184 Histidine box-1.
 MOTIF 217 221 Histidine box-2.
 MOTIF 382 386 Histidine box-3.  

Keyword

 Alternative splicing; Complete proteome; Electron transport; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Membrane; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 444 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004768; F:stearoyl-CoA 9-desaturase activity; IEA:Compara.
 GO:0036109; P:alpha-linolenic acid metabolic process; TAS:Reactome.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0043651; P:linoleic acid metabolic process; TAS:Reactome.
 GO:0006636; P:unsaturated fatty acid biosynthetic process; TAS:ProtInc. 

Interpro

 IPR001199; Cyt_B5-like_heme/steroid-bd.
 IPR012171; Fatty_acid/sphinglp_desaturase.
 IPR005804; Fatty_acid_desaturase-1. 

Pfam

 PF00173; Cyt-b5
 PF00487; FA_desaturase 

SMART

  

PROSITE

 PS00191; CYTOCHROME_B5_1
 PS50255; CYTOCHROME_B5_2 

PRINTS