UniProt Accession

 RAP1A_MOUSE; P62835; P10113 

Genbank Protein ID

 BC051419; BC083128 

Genbank Nucleotide ID

 AAH51419.1; AAH83128.1 

Protein Name

 Ras-related protein Rap-1A 

Protein Synonyms/Alias

 Ras-related protein Krev-1 

Gene Name

 Rap1a 

Gene Synonyms/Alias

 Krev-1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
5	***MREYKLVVLGSG	ubiquitination	[1]
31	VQGIFVEKYDPTIED	ubiquitination	[1]
117	PMILVGNKCDLEDER	ubiquitination	[1]
128	EDERVVGKEQGQNLA	ubiquitination	[1]
149	AFLESSAKSKINVNE	ubiquitination	[1]
151	LESSAKSKINVNEIF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). 

Sequence Annotation

 NP_BIND 10 17 GTP (By similarity).
 NP_BIND 57 61 GTP (By similarity).
 NP_BIND 116 119 GTP (By similarity).
 MOTIF 32 40 Effector region (Probable).
 MOD_RES 181 181 Cysteine methyl ester (By similarity).
 LIPID 181 181 S-geranylgeranyl cysteine (By  

Keyword

 Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 184 AA 

Protein Sequence

Gene Ontology

 GO:0032045; C:guanyl-nucleotide exchange factor complex; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IDA:MGI.
 GO:0032403; F:protein complex binding; ISS:UniProtKB.
 GO:0008565; F:protein transporter activity; ISS:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.