CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024418
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein LCHN 
Protein Synonyms/Alias
  
Gene Name
 LCHN 
Gene Synonyms/Alias
 KIAA1147 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
152LERGARMKSVGILSPubiquitination[1, 2, 3, 4]
352DHLQPLLKINSADREubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 455 AA 
Protein Sequence
MVEQGDAAPL LRWAEGPAVS LPQAPQPQAG GWGRGGGGGA RPAAEPPRRR EPEEPAAPEV 60
LLQPGRLELG DVEEDQVVAV FVVTFDPRSG NMVEWCLPQD IDLEGVEFKS MASGSHKIQS 120
DFIYFRKGPF FGLACFANMP VESELERGAR MKSVGILSPS YTLLYRYMHF LENQVRHQLE 180
MPGHYSHLAA FYEDKKGVLH AGPGRGSSLP PVYWLPSIHR YMYPEMKITH PAGCMSQFIK 240
FFGEQILILW KFALLRKRIL IFSPPPVGVV CYRVYCCCCL ANVSLPGIGG TIPESKPFFY 300
VNVADIESLE VEVSYVACTT EKIFEEKREL YDVYVDNQNV KTHHDHLQPL LKINSADREK 360
YRRLNEQRQM LLYSQEVEED YNPCEEDLFV LFFLEQNNRI FQTLLEVSAS QDKTLTAEHA 420
RGMGLDPQGD RSFLLDLLEA YGIDVMLVID NPCCP 455 
Gene Ontology
  
Interpro
 IPR018626; DUF2347. 
Pfam
 PF09804; DUF2347 
SMART
  
PROSITE
  
PRINTS