UniProt Accession

 PHB2_RAT; Q5XIH7; P70629; P70630 

Genbank Protein ID

 BC083705; U75391; U75392 

Genbank Nucleotide ID

 AAH83705.1; AAB18746.1; AAB18747.1 

Protein Name

 Prohibitin-2 

Protein Synonyms/Alias

 B-cell receptor-associated protein BAP37; BAP-37 

Gene Name

 Phb2 

Gene Synonyms/Alias

 Bcap37 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
97	ISSPTGSKDLQMVNI	acetylation	[1]
142	SIVNEVLKSVVAKFN	acetylation	[1]
147	VLKSVVAKFNASQLI	acetylation	[1]
200	YTAAVEAKQVAQQEA	acetylation	[1]
216	RAQFLVEKAKQEQRQ	acetylation	[1]
236	EGEAEAAKMLGEALS	acetylation	[1]
244	MLGEALSKNPGYIKL	acetylation	[1]
250	SKNPGYIKLRKIRAA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity). 

Sequence Annotation

 REGION 19 49 Necessary for transcriptional repression
 REGION 150 174 Necessary for transcriptional repression
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 128 128 Phosphotyrosine (By similarity).
 MOD_RES 250 250 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleus; Phosphoprotein; Receptor; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 299 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0060749; P:mammary gland alveolus development; IEA:Compara.
 GO:0060744; P:mammary gland branching involved in thelarche; IEA:Compara.
 GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IEA:Compara.
 GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001107; Band_7.
 IPR000163; Prohibitin. 

Pfam

 PF01145; Band_7 

SMART

 SM00244; PHB 

PROSITE

  

PRINTS

 PR00679; PROHIBITIN.