| Tag | Content |
|---|
| CPLM ID | CPLM-013296 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Paraspeckle component 1 |
Protein Synonyms/Alias | |
Gene Name | Pspc1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 379 | RRQQEGFKPNYMENR | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Together with NONO, required for the formation of nuclear paraspeckles. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers (By similarity). |
Sequence Annotation | DOMAIN 81 153 RRM 1.
DOMAIN 155 236 RRM 2.
REGION 124 357 Sufficient for paraspeckles localization
REGION 230 357 Sufficient for perinucleolar caps
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 408 408 Phosphoserine (By similarity).
MOD_RES 472 472 Phosphoserine (By similarity).
MOD_RES 476 476 Phosphoserine (By similarity).
MOD_RES 508 508 Phosphoserine (By similarity). |
Keyword | Acetylation; Activator; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 522 AA |
Protein Sequence | MMLRGNLKQV RIEKNPARLR ALESAAGESE PVAAAAMALT LAGEQPPPPA PSEEHPDEEM 60
GFTIDIKSFL KPGEKTYTQR CRLFVGNLPT DITEEDFKRL FERYGEPSEV FINRDRGFGF 120
IRLESRTLAE IAKAELDGTI LKSRPLRIRF ATHGAALTVK NLSPVVSNEL LEQAFSQFGP 180
VEKAVVVVDD RGRATGKGFV EFAAKPPARK ALERCGDGAF LLTTTPRPVI VEPMEQFDDE 240
DGLPEKLMQK TQQYHKEREQ PPRFAQPGTF EFEYASRWKA LDEMEKQQRE QVDRNIREAK 300
EKLEAEMEAA RHEHQLMLMR QDLMRRQEEL RRLEELRNQE LQKRKQIQLR HEEEHRRREE 360
EMIRHREQEE LRRQQEGFKP NYMENREQEM RMGDMGPRGA INMGDAFSPA PAGTQGPPPM 420
MGMNMNNRGT IPGPPMGPGP AMGPEGAANM GTPMIPDNGA VHNDRFPQGP PSQMGSPMGN 480
RTGSETPQAP MSAVGPVSGG PGGFGRGSQG GNFEGPNKRR RY 522 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell. GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. GO:0042382; C:paraspeckles; IEA:Compara. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |