CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041630
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Neurofilament medium polypeptide 
Protein Synonyms/Alias
  
Gene Name
 Nefm 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
100KLSRSNEKEQLQGLNacetylation[1]
125HYLEQQNKEIEAEIHacetylation[1]
184EEDIHRLKERFEEEAacetylation[1]
206AAIRALRKDIEESSMacetylation[1]
220MVKVELDKKVQSLQDacetylation[1]
269TDISTALKEIRSQLEacetylation[1]
296WFKCRYAKLTEAAEQacetylation[1]
305TEAAEQNKEAIRSAKacetylation[1]
312KEAIRSAKEEIAEYRacetylation[1]
400IPVSARAKLLEGEETacetylation[1]
443KTKVEAPKLKVQHKFacetylation[1]
615PVEEVKPKPEAKAGKacetylation[1]
680EEMITITKSVKVSLEubiquitination[2]
683ITITKSVKVSLEKDTubiquitination[2]
799EGGDGATKYITKSVTacetylation[1]
838VTSHAIVKEVTQGD*acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Coiled coil; Complete proteome; Intermediate filament; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 844 AA 
Protein Sequence
MSYTLDSLGN PSAYRRVTET RSSFSRVSGS PSSGFRSQSW SRGSPSTVSS SYKRSALAPR 60
LAYSSAMLSS AESSLDFSQS SSLLNGGSGG DYKLSRSNEK EQLQGLNDRF AGYIEKVHYL 120
EQQNKEIEAE IHALRQKQAS HAQLGDAYDQ EIRELRATLE MVNHEKAQVQ LDSDHLEEDI 180
HRLKERFEEE ARLRDDTEAA IRALRKDIEE SSMVKVELDK KVQSLQDEVA FLRSNHEEEV 240
ADLLAQIQAS HITVERKDYL KTDISTALKE IRSQLECHSD QNMHQAEEWF KCRYAKLTEA 300
AEQNKEAIRS AKEEIAEYRR QLQSKSIELE SVRGTKESLE RQLSDIEERH NHDLSSYQVG 360
TAAARPACAS ASASAAPSAR PKALLVALPG GGIPVSARAK LLEGEETRFS TFSGSITGPL 420
YTHRQPSVTI SSKIQKTKVE APKLKVQHKF VEEIIEETKV EDEKSEMEDA LTVIAEELAA 480
SAKEEKEEAE EKEEEPEVEK SPVKSPEAKE EEEGEKEEEE EGQEEEEEED EGVKSDQAEE 540
GGSEKEGSSE KDEGEQEEEG ETEAEGEGEE AEAKEEKKTE GKVEEMAIKE EIKVEKPEKA 600
KSPVPKSPVE EVKPKPEAKA GKDEQKEEEK VEEKKEVAKE SPKEEKVEKK EEKPKDVPDK 660
KKAESPVKEK AVEEMITITK SVKVSLEKDT KEEKPQQQEK VKEKAEEEGG SEEEVGDKSP 720
QESKKEDIAI NGEVEGKEEE EQETQEKGSG QEEEKGVVTN GLDVSPAEEK KGEDRSDDKV 780
VVTKKVEKIT SEGGDGATKY ITKSVTVTQK VEEHEETFEE KLVSTKKVEK VTSHAIVKEV 840
TQGD 844 
Gene Ontology
 GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR006821; Intermed_filament_DNA-bd. 
Pfam
 PF00038; Filament
 PF04732; Filament_head 
SMART
  
PROSITE
  
PRINTS