CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036101
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Methyltransferase-like protein 14 
Protein Synonyms/Alias
  
Gene Name
 METTL14 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
110DRFEEYPKLRELIRLubiquitination[1, 2, 3, 4]
118LRELIRLKDELIAKSubiquitination[2, 4]
240KTKTLDPKAVFQRTKubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 418 AA 
Protein Sequence
MSREKLLKQE KLAGLPMIPL LQMQNVSIWM KERQMKTKWK NIRQVEKMQQ DEENLPYEEE 60
IYKDSSTFLK GTQSLNPHND YCQHFVDTGH RPQNFIRDVG LADRFEEYPK LRELIRLKDE 120
LIAKSNTPPM YLQADIEAFD IRELTPKFDV ILLEPPLEEY YRETGITANE KCWTWDDIMK 180
LEIDEIAAPR SFIFLWCGSG EGLDLGRVCL RKWGYRRCED ICWIKTNKNN PGKTKTLDPK 240
AVFQRTKEHC LMGIKGTVKR STDGDFIHAN VDIDLIITEE PEIGNIEKPV EIFHIIEHFC 300
LGRRRLHLFG RDSTIRPGWL TVGPTLTNSN YNAETYASYF SAPNSYLTGC TEEIERLRPK 360
SPPPKSKSDR GGGAPRGGGR GGTSAGRGRE RNRSNFRGER GGFRGGRGGA HRGGFPPR 418 
Gene Ontology
 GO:0008168; F:methyltransferase activity; IEA:InterPro.
 GO:0032259; P:methylation; IEA:GOC.
 GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro. 
Interpro
 IPR007757; MT-A70-like. 
Pfam
 PF05063; MT-A70 
SMART
  
PROSITE
 PS51143; MT_A70 
PRINTS