UniProt Accession

 NTAN1_MOUSE; Q64311 

Genbank Protein ID

 U57692; U57691; BC030172 

Genbank Nucleotide ID

 AAB66490.1; AAC52885.1; AAH30172.1 

Protein Name

 Protein N-terminal asparagine amidohydrolase 

Protein Synonyms/Alias

 Protein NH2-terminal asparagine amidohydrolase; PNAA; Protein NH2-terminal asparagine deamidase; PNAD; Protein N-terminal Asn amidase; Protein NTN-amidase 

Gene Name

 Ntan1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
276	RSTLMFLKKFPSPEN	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Hydrolase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 310 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0008418; F:protein-N-terminal asparagine amidohydrolase activity; IDA:MGI.
 GO:0008344; P:adult locomotory behavior; IMP:MGI.
 GO:0007613; P:memory; IMP:MGI. 

Interpro

 IPR026750; NTAN1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS