UniProt Accession

 ALR_MOUSE; P56213; Q8CIF8; Q9JJE6 

Genbank Protein ID

 U40494; AB041561; AK146579; CH466606; BC023941; AF148688 

Genbank Nucleotide ID

 AAD10339.1; BAA95045.1; BAE27275.1; EDL22354.1; AAH23941.1; AAD36987.1 

Protein Name

 FAD-linked sulfhydryl oxidase ALR 

Protein Synonyms/Alias

 Augmenter of liver regeneration 

Gene Name

 Gfer 

Gene Synonyms/Alias

 Alr; MNCb-0663 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
173	LHNEVNRKLGKPDFD	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen (By similarity). 

Sequence Annotation

 DOMAIN 88 188 ERV/ALR sulfhydryl oxidase.
 NP_BIND 92 100 FAD (By similarity).
 NP_BIND 164 176 FAD (By similarity).
 NP_BIND 187 188 FAD (By similarity).
 BINDING 104 104 FAD (By similarity).
 BINDING 133 133 FAD (By similarity).
 DISULFID 88 88 Interchain (with C-197) (By similarity).
 DISULFID 135 138 Redox-active (By similarity).
 DISULFID 164 181 By similarity.
 DISULFID 197 197 Interchain (with C-88) (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Disulfide bond; FAD; Flavoprotein; Growth factor; Mitochondrion; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0050660; F:flavin adenine dinucleotide binding; ISS:UniProtKB.
 GO:0015035; F:protein disulfide oxidoreductase activity; ISS:UniProtKB.
 GO:0016972; F:thiol oxidase activity; IEA:EC. 

Interpro

 IPR017905; ERV/ALR_sulphydryl_oxidase.
 IPR006863; Evr1_Alr. 

Pfam

 PF04777; Evr1_Alr 

SMART

  

PROSITE

 PS51324; ERV_ALR 

PRINTS