CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016231
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine zipper protein 1 
Protein Synonyms/Alias
  
Gene Name
 LUZP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MAEFTSYKETASSRHubiquitination[1]
604SKAPVLSKYPYSCRSubiquitination[2]
882SRSSIIIKPSDPVERubiquitination[1]
902PAETIRWKSHSAPSEubiquitination[1]
931WKSRRDLKSLEDPPTubiquitination[1]
942DPPTRIGKNVESTNSubiquitination[1, 3, 4]
1051DPSELPGKQGLPESGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 394 394 Phosphoserine.
 MOD_RES 570 570 Phosphoserine.
 MOD_RES 574 574 Phosphoserine.
 MOD_RES 611 611 Phosphoserine.
 MOD_RES 659 659 Phosphoserine.
 MOD_RES 679 679 Phosphothreonine.
 MOD_RES 690 690 Phosphoserine.
 MOD_RES 745 745 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1076 AA 
Protein Sequence
MAEFTSYKET ASSRHLRFKL QSLSRRLDEL EEATKNLQKA EDELLDLQDK VIQAEGSNSS 60
MLAEIEVLRQ RVLRIEGKDE EIKRAEDLCR LMKEKLEEEE NLTRELKSEI ERLQKRMAEL 120
EKLEEAFSRS KNDCTQLCLS LNEERNLTKK ISSELEMLRV KVKELESSED RLDKTEQSLA 180
SELEKLKSLT LSFVSERKYL NEKEKENEKL IKELTQKLEQ NKKMNRDYTR NASNLERNDL 240
RIEDGISSTL PSKESRRKGG LDYLKQVENE TRNKSENEKN RNQEDNKVKD LNQEIEKLKT 300
QIKHFESLEE ELKKMKSKNN DLQDNYLSEQ NKNKLLASQL EEIKLQIKKQ KELENGEVEG 360
EDAFLSSKGR HERTKFRGHG SEASVSKHTA RELSPQHKRE RLRNREFALN NENYSLSNRQ 420
VSSPSFTNRR AAKASHMGVS TDSGTQETKK TEDRFVPGSS QSEGKKSREQ PSVLSRYPPA 480
AQEHSKAWKG TSKPGTESGL KGKVEKTTRT FSDTTHGSVP SDPLGRADKA SDTSSETVFG 540
KRGHVLGNGS QVTQAANSGC SKAIGALASS RRSSSEGLSK GKKAANGLEA DNSCPNSKAP 600
VLSKYPYSCR SQENILQGFS TSHKEGVNQP AAVVMEDSSP HEALRCRVIK SSGREKPDSD 660
DDLDIASLVT AKLVNTTITP EPEPKPQPNS REKAKTRGAP RTSLFENDKD AGMENESVKS 720
VRASTNTMEL PDTNGAGVKS QRPFSPREAL RSRAIIKPVI VDKDVKKIMG GSGTETTLEK 780
QKPVSKPGPN KVTSSITIYP SDSSSPRAAP GEALRERHTS TSNIQVGLAE LTSVSNHVSS 840
PFELSIHKHD ITLQLAEAER MADGPLKDRP ETVVSRSSII IKPSDPVERN SHAPPAETIR 900
WKSHSAPSEV GFSDARHVTV RNAWKSRRDL KSLEDPPTRI GKNVESTNSN AYTQRSSTDF 960
SELEQPRSCL FEQGTRRVGP SSGDAPEPSS RRTQSSLTVS EVLTRRNRVG DTITVAAWNH 1020
SASMEEEGED CTLSVYRQLH NSLDPSELPG KQGLPESGRV RAEERLRPTR PCAEEN 1076 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0060840; P:artery development; IEA:Compara.
 GO:0021503; P:neural fold bending; IEA:Compara.
 GO:0003281; P:ventricular septum development; IEA:Compara. 
Interpro
 IPR026734; Luzp1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS