CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004425
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin-1 
Protein Synonyms/Alias
 ANK-1; Ankyrin-R; Erythrocyte ankyrin 
Gene Name
 ANK1 
Gene Synonyms/Alias
 ANK 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
41NRSRDRKKKADAATSacetylation[1]
42RSRDRKKKADAATSFacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. 
Sequence Annotation
 REPEAT 44 73 ANK 1.
 REPEAT 77 106 ANK 2.
 REPEAT 110 139 ANK 3.
 REPEAT 143 172 ANK 4.
 REPEAT 174 201 ANK 5.
 REPEAT 205 234 ANK 6.
 REPEAT 238 267 ANK 7.
 REPEAT 271 300 ANK 8.
 REPEAT 304 333 ANK 9.
 REPEAT 337 366 ANK 10.
 REPEAT 370 399 ANK 11.
 REPEAT 403 432 ANK 12.
 REPEAT 436 465 ANK 13.
 REPEAT 469 498 ANK 14.
 REPEAT 502 531 ANK 15.
 REPEAT 535 564 ANK 16.
 REPEAT 568 597 ANK 17.
 REPEAT 601 630 ANK 18.
 REPEAT 634 663 ANK 19.
 REPEAT 667 696 ANK 20.
 REPEAT 700 729 ANK 21.
 REPEAT 733 762 ANK 22.
 REPEAT 766 795 ANK 23.
 DOMAIN 911 1066 ZU5 1.
 DOMAIN 1067 1233 ZU5 2.
 DOMAIN 1403 1487 Death.
 REGION 1 827 89 kDa domain.
 REGION 1234 1362 UPA domain (By similarity).
 REGION 1383 1881 55 kDa regulatory domain.
 MOD_RES 105 105 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 233 233 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 431 431 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 464 464 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 629 629 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 662 662 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 695 695 (3S)-3-hydroxyaspartate; by HIF1AN;
 MOD_RES 728 728 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 761 761 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 856 856 Phosphoserine (By similarity).
 MOD_RES 1073 1073 Phosphotyrosine (By similarity).  
Keyword
 3D-structure; Alternative promoter usage; Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Elliptocytosis; Hereditary hemolytic anemia; Hydroxylation; Lipoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Sarcoplasmic reticulum. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1881 AA 
Protein Sequence
MAQAAKQLKK IKDIEAQALQ EQKEKEESNR KRRNRSRDRK KKADAATSFL RAARSGNLDK 60
ALDHLRNGVD INTCNQNGLN GLHLASKEGH VKMVVELLHK EIILETTTKK GNTALHIAAL 120
AGQDEVVREL VNYGANVNAQ SQKGFTPLYM AAQENHLEVV KFLLENGANQ NVATEDGFTP 180
LAVALQQGHE NVVAHLINYG TKGKVRLPAL HIAARNDDTR TAAVLLQNDP NPDVLSKTGF 240
TPLHIAAHYE NLNVAQLLLN RGASVNFTPQ NGITPLHIAS RRGNVIMVRL LLDRGAQIET 300
KTKDELTPLH CAARNGHVRI SEILLDHGAP IQAKTKNGLS PIHMAAQGDH LDCVRLLLQY 360
DAEIDDITLD HLTPLHVAAH CGHHRVAKVL LDKGAKPNSR ALNGFTPLHI ACKKNHVRVM 420
ELLLKTGASI DAVTESGLTP LHVASFMGHL PIVKNLLQRG ASPNVSNVKV ETPLHMAARA 480
GHTEVAKYLL QNKAKVNAKA KDDQTPLHCA ARIGHTNMVK LLLENNANPN LATTAGHTPL 540
HIAAREGHVE TVLALLEKEA SQACMTKKGF TPLHVAAKYG KVRVAELLLE RDAHPNAAGK 600
NGLTPLHVAV HHNNLDIVKL LLPRGGSPHS PAWNGYTPLH IAAKQNQVEV ARSLLQYGGS 660
ANAESVQGVT PLHLAAQEGH AEMVALLLSK QANGNLGNKS GLTPLHLVAQ EGHVPVADVL 720
IKHGVMVDAT TRMGYTPLHV ASHYGNIKLV KFLLQHQADV NAKTKLGYSP LHQAAQQGHT 780
DIVTLLLKNG ASPNEVSSDG TTPLAIAKRL GYISVTDVLK VVTDETSFVL VSDKHRMSFP 840
ETVDEILDVS EDEGTAHITI MGEELISFKA ERRDSRDVDE EKELLDFVPK LDQVVESPAI 900
PRIPCAMPET VVIRSEEQEQ ASKEYDEDSL IPSSPATETS DNISPVASPV HTGFLVSFMV 960
DARGGSMRGS RHNGLRVVIP PRTCAAPTRI TCRLVKPQKL STPPPLAEEE GLASRIIALG 1020
PTGAQFLSPV IVEIPHFASH GRGDRELVVL RSENGSVWKE HRSRYGESYL DQILNGMDEE 1080
LGSLEELEKK RVCRIITTDF PLYFVIMSRL CQDYDTIGPE GGSLKSKLVP LVQATFPENA 1140
VTKRVKLALQ AQPVPDELVT KLLGNQATFS PIVTVEPRRR KFHRPIGLRI PLPPSWTDNP 1200
RDSGEGDTTS LRLLCSVIGG TDQAQWEDIT GTTKLVYANE CANFTTNVSA RFWLSDCPRT 1260
AEAVNFATLL YKELTAVPYM AKFVIFAKMN DPREGRLRCY CMTDDKVDKT LEQHENFVEV 1320
ARSRDIEVLE GMSLFAELSG NLVPVKKAAQ QRSFHFQSFR ENRLAMPVKV RDSSREPGGS 1380
LSFLRKAMKY EDTQHILCHL NITMPPCAKG SGAEDRRRTP TPLALRYSIL SESTPGSLSG 1440
TEQAEMKMAV ISEHLGLSWA ELARELQFSV EDINRIRVEN PNSLLEQSVA LLNLWVIREG 1500
QNANMENLYT ALQSIDRGEI VNMLEGSGRQ SRNLKPDRRH TDRDYSLSPS QMNGYSSLQD 1560
ELLSPASLGC ALSSPLRADQ YWNEVAVLDA IPLAATEHDT MLEMSDMQVW SAGLTPSLVT 1620
AEDSSLECSK AEDSDATGHE WKLEGALSEE PRGPELGSLE LVEDDTVDSD ATNGLIDLLE 1680
QEEGQRSEEK LPGSKRQDDA TGAGQDSENE VSLVSGHQRG QARITHSPTV SQVTERSQDR 1740
LQDWDADGSI VSYLQDAAQG SWQEEVTQGP HSFQGTSTMT EGLEPGGSQE YEKVLVSVSE 1800
HTWTEQPEAE SSQADRDRRQ QGQEEQVQEA KNTFTQVVQG NEFQNIPGEQ VTEEQFTDEQ 1860
GNIVTKKIIR KVVRQIDLSS ADAAQEHEED HTSTPNP 1897 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; NAS:UniProtKB.
 GO:0030863; C:cortical cytoskeleton; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0031430; C:M band; IEA:UniProtKB-SubCell.
 GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0014731; C:spectrin-associated cytoskeleton; IDA:BHF-UCL.
 GO:0008093; F:cytoskeletal adaptor activity; TAS:UniProtKB.
 GO:0019899; F:enzyme binding; TAS:UniProtKB.
 GO:0030507; F:spectrin binding; NAS:UniProtKB.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0007010; P:cytoskeleton organization; NAS:UniProtKB.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IDA:BHF-UCL.
 GO:0048821; P:erythrocyte development; IEA:Compara.
 GO:0006887; P:exocytosis; NAS:UniProtKB.
 GO:0045199; P:maintenance of epithelial cell apical/basal polarity; TAS:UniProtKB.
 GO:0015672; P:monovalent inorganic cation transport; IEA:Compara.
 GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:Compara.
 GO:0072661; P:protein targeting to plasma membrane; IMP:BHF-UCL.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR000906; ZU5. 
Pfam
 PF00023; Ank
 PF00531; Death
 PF00791; ZU5 
SMART
 SM00248; ANK
 SM00005; DEATH
 SM00218; ZU5 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50017; DEATH_DOMAIN
 PS51145; ZU5 
PRINTS
 PR01415; ANKYRIN.