| Tag | Content |
|---|
| CPLM ID | CPLM-000184 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Peroxiredoxin-4 |
Protein Synonyms/Alias | Antioxidant enzyme AOE372; Peroxiredoxin IV; Prx-IV; Thioredoxin peroxidase AO372; Thioredoxin-dependent peroxide reductase A0372 |
Gene Name | Prdx4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 253 | EVCPAGWKPGSETII | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. |
Sequence Annotation | DOMAIN 82 240 Thioredoxin.
ACT_SITE 127 127 Cysteine sulfenic acid (-SOH)
DISULFID 127 127 Interchain (with C-248); in linked form
DISULFID 248 248 Interchain (with C-127); in linked form |
Keyword | Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Oxidoreductase; Peroxidase; Redox-active center; Reference proteome; Secreted; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 274 AA |
Protein Sequence | MEARSKLLDG TTASRRWTRK LVLLLPPLLL FLLRTESLQG LESDERFRTR ENECHFYAGG 60
QVYPGEASRV SVADHSLHLS KAKISKPAPY WEGTAVINGE FKELKLTDYR GKYLVFFFYP 120
LDFTFVCPTE IIAFGDRIEE FKSINTEVVA CSVDSQFTHL AWINTPRRQG GLGPIRIPLL 180
SDLNHQISKD YGVYLEDSGH TLRGLFIIDD KGVLRQITLN DLPVGRSVDE TLRLVQAFQY 240
TDKHGEVCPA GWKPGSETII PDPAGKLKYF DKLN 274 |
Gene Ontology | GO:0005615; C:extracellular space; IEA:Compara. GO:0005739; C:mitochondrion; IDA:MGI. GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW. GO:0051920; F:peroxiredoxin activity; IEA:EC. GO:0072593; P:reactive oxygen species metabolic process; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |