CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032083
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Active breakpoint cluster region-related protein 
Protein Synonyms/Alias
 cDNA FLJ54747, highly similar to Active breakpoint cluster region-related protein 
Gene Name
 ABR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
165ELEDMKMKISALKSEubiquitination[1]
170KMKISALKSEIQKEKubiquitination[1]
363YDKTKVNKDNNEIVDubiquitination[1]
375IVDKIMGKGQIQLDPubiquitination[1]
441VTKRERSKVPYIVRQubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTPase activation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 641 AA 
Protein Sequence
MEILLIIRFC CNCTYALLYK PIDRVTRSTL VLHDLLKHTP VDHPDYPLLQ DALRISQNFL 60
SSINEDIDPR RTAVTTPKGE TRQLVKDGFL VEVSESSRKL RHVFLFTDVL LCAKLKKTSA 120
GKHQQYDCKW YIPLADLVFP SPEESEASPQ VHPFPDHELE DMKMKISALK SEIQKEKANK 180
GQSRAIERLK KKMFENEFLL LLNSPTIPFR IHNRNGKSYL FLLSSDYERS EWREAIQKLQ 240
KKDLQAFVLS SVELQVLTGS CFKLRTVHNI PVTSNKDDDE SPGLYGFLHV IVHSAKGFKQ 300
SANLYCTLEV DSFGYFVSKA KTRVFRDTAE PKWDEEFEIE LEGSQSLRIL CYEKCYDKTK 360
VNKDNNEIVD KIMGKGQIQL DPQTVETKNW HTDVIEMNGI KVEFSMKFTS RDMSLKRTPS 420
KKQTGVFGVK ISVVTKRERS KVPYIVRQCV EEVEKRGIEE VGIYRISGVA TDIQALKAVF 480
DANNKDILLM LSDMDINAIA GTLKLYFREL PEPLLTDRLY PAFMEGIALS DPAAKENCMM 540
HLLRSLPDPN LITFLFLLEH LKRVAEKEPI NKMSLHNLAT VFGPTLLRPS EVESKAHLTS 600
AADIWSHDVM AQVQVLLYYL QHPPISFAEL KRNTLYFSTD V 641 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF00168; C2
 PF00169; PH
 PF00620; RhoGAP
 PF00621; RhoGEF 
SMART
 SM00239; C2
 SM00233; PH
 SM00324; RhoGAP 
PROSITE
 PS50004; C2
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS50238; RHOGAP 
PRINTS