| Tag | Content |
|---|
| CPLM ID | CPLM-023446 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin carboxyl-terminal hydrolase 7 |
Protein Synonyms/Alias | Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7; Deubiquitinating enzyme 7 |
Gene Name | Usp7 |
Gene Synonyms/Alias | CG1490 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1000 | TTAQGAQKTFRIEEV | acetylation | [1] | | 1123 | SSLNFSEKAIKIYN* | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Cleaves ubiquitin fusion protein substrates (By similarity). |
Sequence Annotation | DOMAIN 101 222 MATH.
ACT_SITE 250 250 Nucleophile (By similarity).
ACT_SITE 490 490 Proton acceptor (By similarity).
MOD_RES 1117 1117 Phosphoserine. |
Keyword | Complete proteome; Hydrolase; Nucleus; Phosphoprotein; Protease; Reference proteome; Thiol protease; Ubl conjugation; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1129 AA |
Protein Sequence | MEIETDQSIE AMDTQDTQEV EILTSDLQQT QQQRNSPPQL PKFKNLIQPQ LHAVGAVTQL 60
PSENGNMPPQ QLLADSSSTS FGDGEAMGID DESKEDQFRS ETTFSFTVEN VVQLKSQRLS 120
PPVYVRMLPW RIMVIPNDRA LGFFLQCNGE NDSPTWSCNA IAELRLKCHK PDAQPFTRAR 180
IKHLFYSKEN DYGYSNFITW QELKDSEKSY VHNNSITLEV HVVADAPHGV LWDSKKHTGY 240
VGLKNQGATC YMNSLLQTLY FTNSLRLSVY RIPTEADDSS KSVGLSLQRV FHELQFGDRP 300
VGTKKLTKSF GWETLDSFMQ HDVQEFLRVL LDKLESKMKG TILEGTIPGL FEGKMSSYIK 360
CKNVDYNSTR YETFYDIQLN IKDKKNIYES FQDYVAPETL EGDNKYDAGV HGLQEASKGV 420
IFTSFPPVLH LHLMRFQYDP VTDSSIKYND RFEFYEHINL DRYLAESENT LADYVLHAVL 480
VHSGDNHGGH YVVFINPKAD GRWFKFDDDV VSSCRKQEAI EQNYGGMDDE ISFHAKCSNA 540
YMLVYIRQSE LDRVLGDITE SEISSDLVER LDLEKRIEMA RRKERGEANT YVSVHVILEE 600
NFEEQHKRRL FDLEKVHPRV FRIKQNQTVD ELVDLFVRGF GVSRQRMRMW NLCTAQTQKF 660
SHFDFVAEGS RTIEQISTSQ KPWVIWLQLA WTDVPGPLPP FNPKTESLLF LKYYDPRNKR 720
LNYIGCTQQP HTRRLIDLVP DVNSKLGFEP DTELTIYDEY ADKKLVNLNE PIESALFIPQ 780
DHLQGHILIF ERENVDAKLD LPTVGDYFLD LVYRIEIIFS DKCNPNEPDF TLELSNRYNY 840
DQLANAVAER LNTDPQKLQF FMCINNYKET AGNAVPYTFK GTIKDLVSYT KQSSTKRIFY 900
QRLSLSIHEL DNKKQFKCVW VSSDLKDEKE LVLYPNKNDT VKGLLEEAAK KISFAENSRR 960
KLRLLKISNH KIVAVCKDDI PLDTLLKSNE SITTAQGAQK TFRIEEVPAE DMQLAENEFL 1020
IPVAHFSKEL YNSFGIPFLT KARQGEPYGA LKQRIQRRLN VQDKEWENYK FCVISMGHNA 1080
DVNDNTPVDL EVYRSWTSGQ LPFFGLDHIN KSRKRSSLNF SEKAIKIYN 1129 |
Gene Ontology | GO:0005634; C:nucleus; ISS:UniProtKB. GO:0005700; C:polytene chromosome; IDA:FlyBase. GO:0043234; C:protein complex; IPI:FlyBase. GO:0035328; C:transcriptionally silent chromatin; IDA:FlyBase. GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro. GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB. GO:0006342; P:chromatin silencing; IGI:FlyBase. GO:0016578; P:histone deubiquitination; IDA:FlyBase. GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |