CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029787
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ephrin type-B receptor 2 
Protein Synonyms/Alias
  
Gene Name
 EPHB2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
756VNSNLVCKVSDFGLSubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 946 AA 
Protein Sequence
MWVPVLALPV CTYAETLMDS TTATAELGWM VHPPSGWEEV SGYDENMNTI RTYQVCNVFE 60
SSQNNWLRTK FIRRRGAHRI HVEMKFSVRD CSSIPSVPGS CKETFNLYYY EADFDSATKT 120
FPNWMENPWV KVDTIAADES FSQVDLGGRV MKINTEVRSF GPVSRSGFYL AFQDYGGCMS 180
LIAVRVFYRK CPRIIQNGAI FQETLSGAES TSLVAARGSC IANAEEVDVP IKLYCNGDGE 240
WLVPIGRCMC KAGFEAVENG TVCRGCPSGT FKANQGDEAC THCPINSRTT SEGATNCVCR 300
NGYYRADLDP LDMPCTTIPS APQAVISSVN ETSLMLEWTP PRDSGGREDL VYNIICKSCG 360
SGRGACTRCG DNVQYAPRQL GLTEPRIYIS DLLAHTQYTF EIQAVNGVTD QSPFSPQFAS 420
VNITTNQAAP SAVSIMHQVS RTVDSITLSW SQPDQPNGVI LDYELQYYEK QELSEYNATA 480
IKSPTNTVTV QGLKAGAIYV FQVRARTVAG YGRYSGKMYF QTMTEAEYQT SIQEKLPLII 540
GSSAAGLVFL IAVVVIAIVC NRRGFERADS EYTDKLQHYT SGHMTPGMKI YIDPFTYEDP 600
NEAVREFAKE IDISCVKIEQ VIGAGEFGEV CSGHLKLPGK REIFVAIKTL KSGYTEKQRR 660
DFLSEASIMG QFDHPNVIHL EGVVTKSTPV MIITEFMENG SLDSFLRQND GQFTVIQLVG 720
MLRGIAAGMK YLADMNYVHR DLAARNILVN SNLVCKVSDF GLSRFLEDDT SDPTYTSALG 780
GKIPIRWTAP EAIQYRKFTS ASDVWSYGIV MWEVMSYGER PYWDMTNQDV INAIEQDYRL 840
PPPMDCPSAL HQLMLDCWQK DRNHRPKFGQ IVNTLDKMIR NPNSLKAMAP LSSGINLPLL 900
DRTIPDYTSF NTVDEWLEAI KMGQYKESFA NAGFTSFDVV SQMMME 946 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005003; F:ephrin receptor activity; IEA:InterPro. 
Interpro
 IPR001090; Ephrin_rcpt_lig-bd_dom.
 IPR003961; Fibronectin_type3.
 IPR008979; Galactose-bd-like.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR013783; Ig-like_fold.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR021129; SAM_type1.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016257; Tyr_kinase_ephrin_rcpt.
 IPR001426; Tyr_kinase_rcpt_V_CS. 
Pfam
 PF01404; Ephrin_lbd
 PF00041; fn3
 PF07699; GCC2_GCC3
 PF07714; Pkinase_Tyr
 PF00536; SAM_1 
SMART
 SM00615; EPH_lbd
 SM00060; FN3
 SM00219; TyrKc 
PROSITE
 PS51550; EPH_LBD
 PS50853; FN3
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00790; RECEPTOR_TYR_KIN_V_1
 PS00791; RECEPTOR_TYR_KIN_V_2
 PS50105; SAM_DOMAIN 
PRINTS
 PR00109; TYRKINASE.