UniProt Accession

 ADPP_YEAST; Q01976; D6VQB0 

Genbank Protein ID

 X78993; Z35980; AY558185; X66247; BK006936 

Genbank Nucleotide ID

 CAA55614.1; CAA85068.1; AAS56511.1; CAA46972.1; DAA07230.1 

Protein Name

 ADP-ribose pyrophosphatase 

Protein Synonyms/Alias

 ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase 

Gene Name

 YSA1 

Gene Synonyms/Alias

 YBR111C; YBR0907 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
55	GLQKIIYKDPNGKER	acetylation	[1]
210	KLDQQGYKLDARVQN	ubiquitination	[2]
226	AQGILMAKQYHIK**	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

  

Sequence Annotation

 DOMAIN 75 214 Nudix hydrolase.
 REGION 64 65 Substrate binding; shared with dimeric
 MOTIF 116 137 Nudix box.
 METAL 115 115 Magnesium 1; via carbonyl oxygen (By
 METAL 131 131 Magnesium 2 (By similarity).
 METAL 131 131 Magnesium 3 (By similarity).
 METAL 135 135 Magnesium 1 (By similarity).
 METAL 135 135 Magnesium 3 (By similarity).
 METAL 185 185 Magnesium 3 (By similarity).
 BINDING 46 46 Substrate (By similarity).
 BINDING 69 69 Substrate; shared with dimeric partner
 BINDING 103 103 Substrate (By similarity).
 BINDING 117 117 Substrate; via amide nitrogen (By
 BINDING 152 152 Substrate (By similarity).  

Keyword

 Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 231 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0047631; F:ADP-ribose diphosphatase activity; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0019693; P:ribose phosphate metabolic process; IDA:SGD. 

Interpro

 IPR020084; NUDIX_hydrolase_CS.
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00293; NUDIX 

SMART

  

PROSITE

 PS51462; NUDIX
 PS00893; NUDIX_BOX 

PRINTS